2019
Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Communications Biology 2019, 2: 113. PMID: 30937396, PMCID: PMC6433901, DOI: 10.1038/s42003-019-0355-0.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumClaudin-19Retinal neurogenesisP1 waveOuter nuclear layerRPE signature genesARPE19 cell lineOcular involvementKidney diseaseVisual functionFamilial hypomagnesaemiaNuclear layerBipolar cellsNewborn miceOcular diseasesPigment epitheliumRetinal isomeraseDiseaseMiceHuman induced pluripotent cellsRetinal differentiationSignature genesCell linesNeurogenesisInduced pluripotent cells
2017
A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells
Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 2017, 154: 158-168. PMID: 29128844, DOI: 10.1016/j.biomaterials.2017.10.052.Peer-Reviewed Original ResearchConceptsRetinal degenerationNeurosensory retinaRetinal cellsHost retinal pigment epitheliumStem cellsOuter nuclear layerRetinal pigment epitheliumRetinal cell typesElaborate arborsQuantitative RT-PCRLeading causeImmune responseNuclear layerMouse modelPigment epitheliumSubretinal spaceForebrain cellsMinimal immune responseTherapeutic agentsRetinal laminationRT-PCRDegenerationRetinaRetinal organoidsConfocal immunocytochemistry
2011
Differential Expression of Claudins in Retinas during Normal Development and the Angiogenesis of Oxygen-Induced Retinopathy
Luo Y, Xiao W, Zhu X, Mao Y, Liu X, Chen X, Huang J, Tang S, Rizzolo LJ. Differential Expression of Claudins in Retinas during Normal Development and the Angiogenesis of Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2011, 52: 7556-7564. PMID: 21862644, DOI: 10.1167/iovs.11-7185.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood-Retinal BarrierClaudinsDisease Models, AnimalFluorescent Antibody Technique, IndirectGene Expression Regulation, DevelopmentalHumansInfant, NewbornMembrane ProteinsMiceMice, Inbred C57BLNeovascularization, PhysiologicOccludinOxygenPlant LectinsReal-Time Polymerase Chain ReactionRetinaRetinal NeovascularizationRetinal VesselsRetinopathy of PrematurityRNA, Messenger
2001
Defects in the MITFmi / miApical Surface are Associated with a Failure of Outer Segment Elongation
Bumsted K, Rizzolo L, Barnstable C. Defects in the MITFmi / miApical Surface are Associated with a Failure of Outer Segment Elongation. Experimental Eye Research 2001, 73: 383-392. PMID: 11520113, DOI: 10.1006/exer.2001.1048.Peer-Reviewed Original Research