2017
A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells
Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 2017, 154: 158-168. PMID: 29128844, DOI: 10.1016/j.biomaterials.2017.10.052.Peer-Reviewed Original ResearchConceptsRetinal degenerationNeurosensory retinaRetinal cellsHost retinal pigment epitheliumStem cellsOuter nuclear layerRetinal pigment epitheliumRetinal cell typesElaborate arborsQuantitative RT-PCRLeading causeImmune responseNuclear layerMouse modelPigment epitheliumSubretinal spaceForebrain cellsMinimal immune responseTherapeutic agentsRetinal laminationRT-PCRDegenerationRetinaRetinal organoidsConfocal immunocytochemistry
1997
Differentiation and Transdifferentiation of the Retinal Pigment Epithelium
Zhao S, Rizzolo L, Barnstable C. Differentiation and Transdifferentiation of the Retinal Pigment Epithelium. International Review Of Cytology 1997, 171: 225-266. PMID: 9066129, DOI: 10.1016/s0074-7696(08)62589-9.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumCell type-specific moleculesDifferent expression patternsGrowth factorLoss of polarityTranscription factorsEmbryonic developmentLoss of expressionRetinal cell typesExpression patternsPrE cellsFibroblast growth factorBasic fibroblast growth factorPigment epitheliumCell typesRod photoreceptorsUnique moleculesOcular metabolismRPE layerMonolayer culturesWide arrayExpressionCellsMammalsMolecules