2017
Vascular Biology: RPE Barrier☆
Rizzolo L, Ghiassi-Nejad M, Tainsh L. Vascular Biology: RPE Barrier☆. 2017 DOI: 10.1016/b978-0-12-809324-5.01510-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2011
Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium
Rizzolo LJ, Peng S, Luo Y, Xiao W. Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium. Progress In Retinal And Eye Research 2011, 30: 296-323. PMID: 21704180, DOI: 10.1016/j.preteyeres.2011.06.002.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumOuter retinaPigment epitheliumTight junctionsBarrier functionOuter blood-retinal barrierBlood-retinal barrierHuman retinal pigment epitheliumBlood-tissue barriersTight junctional proteinsPhotoreceptor layerNeural retinaMetabolic alterationsRetinaEpitheliumClaudin compositionTransepithelial diffusionStem cellsJunctional proteinsClaudins
2010
Retinal Pigmented Epithelium Barrier
Rizzolo L. Retinal Pigmented Epithelium Barrier. 2010, 101-108. DOI: 10.1016/b978-0-12-374203-2.00132-9.Chapters
2008
Glucose Transporters in Retinal Pigment Epithelium Development
Rizzolo L. Glucose Transporters in Retinal Pigment Epithelium Development. Ophthalmology Research 2008, 185-199. DOI: 10.1007/978-1-59745-375-2_10.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRetinal pigment epitheliumNeural retinaOuter blood-retinal barrierRetinal pigment epithelium developmentBlood-retinal barrierBlood-brain barrierFormation of fenestraeGlucose transporterTight junctionsExpression of GLUT1Systemic endotheliumChoroidal capillariesPigment epitheliumGLUT family membersBasal levelsRetinaEpithelium developmentTranscellular transportTransepithelial transportChoriocapillarisEndothelium
2007
Development and Role of Tight Junctions in the Retinal Pigment Epithelium
Rizzolo LJ. Development and Role of Tight Junctions in the Retinal Pigment Epithelium. International Review Of Cytology 2007, 258: 195-234. PMID: 17338922, DOI: 10.1016/s0074-7696(07)58004-6.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumPigment epitheliumNeural retinaTight junctionsOuter blood-retinal barrierBlood-retinal barrierSlower time courseEpitheliumCell proliferationTissue-specific propertiesTransepithelial diffusionTime courseRetinaParacellular diffusionPhysiological roleEpithelial monolayersSolid tissuesParacellular spaceApical surfaceCulture system
2006
Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions
Luo Y, Fukuhara M, Weitzman M, Rizzolo LJ. Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions. Brain Research 2006, 1110: 55-63. PMID: 16859655, DOI: 10.1016/j.brainres.2006.06.059.Peer-Reviewed Original Research
2002
Claudin 5 Is Transiently Expressed During the Development of the Retinal Pigment Epithelium
Kojima S, Rahner C, Peng S, Rizzolo L. Claudin 5 Is Transiently Expressed During the Development of the Retinal Pigment Epithelium. The Journal Of Membrane Biology 2002, 186: 81-88. PMID: 11944085, DOI: 10.1007/s00232-001-0137-7.Peer-Reviewed Original ResearchConceptsReverse transcriptase-polymerase chain reactionRetinal pigment epitheliumClaudin-5Chick retinal pigment epitheliumPigment epitheliumTranscriptase-polymerase chain reactionEmbryonic day 14Tight junctionsSemiquantitative RT-PCRExpression of claudinsEmbryonic day 10Northern blottingNeural retinaDay 14Semi-quantitative RT-PCRDay 10Claudin-3RPE developmentPeak levelsDay 7 embryosChoroid layerPrimary culturesChain reactionEpitheliumBlotting
2000
Two secreted retinal factors regulate different stages of development of the outer blood–retinal barrier
Ban Y, Wilt S, Rizzolo L. Two secreted retinal factors regulate different stages of development of the outer blood–retinal barrier. Brain Research 2000, 119: 259-267. PMID: 10675776, DOI: 10.1016/s0165-3806(99)00183-2.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AgonistsAnimalsBiological TransportBlood-Brain BarrierCatecholaminesCell FractionationCells, CulturedChick EmbryoChromatography, GelCulture Media, ConditionedDopamine AgonistsElectric ImpedanceEndopeptidasesEye ProteinsIndolesPigment Epithelium of EyeSerotonin Receptor AgonistsTight JunctionsConceptsRetinal pigment epitheliumBlood-retinal barrierTransepithelial electrical resistanceOuter blood-retinal barrierBlood-brain barrierEffects of astrocytesCultured retinal pigment epitheliumChick retinal pigment epitheliumPigment epitheliumNeural retinaRetinal factorsChick retinaRPE barrierRPE cellsRetinaEndothelial regionAstrocytesTight junctionsCulture modelDiffusible factorsDifferent stagesActive factorsJunction developmentMultistep processFactors
1997
Remodeling of junctional complexes during the development of the outer blood‐retinal barrier
Williams C, Rizzolo L. Remodeling of junctional complexes during the development of the outer blood‐retinal barrier. The Anatomical Record 1997, 249: 380-388. PMID: 9372172, DOI: 10.1002/(sici)1097-0185(199711)249:3<380::aid-ar9>3.0.co;2-y.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumApical junctional complexOuter blood-retinal barrierBlood-retinal barrierNeural retinaZO-1Junctional complexesOccludin expressionRPE developmentMature retinal pigment epitheliumRPE/choroidZO-1 expressionTight junction proteinsEmbryonic day 3Same molecular massEmbryonic day 10Adherens junctionsPigment epitheliumDay 3Day 10Homologous complexesMolecular massRetinaJunction proteinsJunction permeabilityPolarity and the development of the outer blood-retinal barrier.
Rizzolo L. Polarity and the development of the outer blood-retinal barrier. Cellular And Molecular Biology 1997, 12: 1057-67. PMID: 9302567.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1994
The neural retina maintains integrins in the apical membrane of the RPE early in development.
Rizzolo L, Zhou S, Li Z. The neural retina maintains integrins in the apical membrane of the RPE early in development. Investigative Ophthalmology & Visual Science 1994, 35: 2567-76. PMID: 8163344.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumNeural retinaAlpha 6Alpha 3Photoreceptor cell layerSubunit alpha 3Apical membraneBasolateral membraneBeta 1 subunitPigment epitheliumDistribution of integrinsBeta 1 familyRetinaBeta 1Interphotoreceptor matrixExplant culturesCell layerBasal membraneRetinal interfaceEpitheliumIndividual integrinsIntegrin distributionIntegrinsIntercellular interactionsChicken development