2024
Combined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysis
2021
Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions
Kuohn LR, Herman AL, Soto AL, Brown SC, Gilmore EJ, Hirsch LJ, Matouk CC, Sheth KN, Kim JA. Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions. Journal Of Stroke And Cerebrovascular Diseases 2021, 31: 106155. PMID: 34688213, PMCID: PMC8766898, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106155.Peer-Reviewed Original ResearchConceptsIschemic stroke survivorsIV-tPADecompressive craniectomyHospital revisitsStroke survivorsAcute stroke interventionAcute ischemic strokeAcute stroke careProportional hazards regressionImpact of therapyHistory of epilepsyAcute seizuresHospital seizuresIschemic strokeStroke severityPrimary outcomeStroke interventionStroke treatmentStroke careHazards regressionMultivariable modelRetrospective analysisCumulative rateClaims dataPatientsHigh epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage
Kim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2021, 141: 139-146. PMID: 33812771, PMCID: PMC8429508, DOI: 10.1016/j.clinph.2021.01.022.Peer-Reviewed Original ResearchConceptsED burdenSubarachnoid hemorrhageEpileptiform dischargesCerebral ischemiaSAH patientsHigh riskOnset of DCIMajor risk periodContinuous EEG recordingsDCI patientsDCI riskRetrospective analysisNovel biomarkersGroup-based trajectory analysisRisk periodPatientsDay 3.5DCIBurdenHemorrhageIschemiaRiskEEG recordingsBurden rateUseful parameter
2020
Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions
Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.Peer-Reviewed Original ResearchConceptsLong-term seizure freedomSeizure freedomSeizure frequencyElectrode implantationIntracranial studiesLong-term seizure reductionAdditional surgical interventionSeizure onset localizationIntracranial electroencephalogram monitoringSeizure reductionConsecutive patientsSurgical interventionEpileptogenic networksElectroencephalogram monitoringNeuromodulatory effectsRetrospective analysisIntracranial monitoringTransient improvementDepth electrodesPatientsYear 4ImplantationAdequate dataYears
2006
Predictors of Lamotrigine‐associated Rash
Hirsch LJ, Weintraub DB, Buchsbaum R, Spencer HT, Straka T, Hager M, Resor SR. Predictors of Lamotrigine‐associated Rash. Epilepsia 2006, 47: 318-322. PMID: 16499755, DOI: 10.1111/j.1528-1167.2006.00423.x.Peer-Reviewed Original ResearchConceptsAntiepileptic drugsRisk factorsColumbia Comprehensive Epilepsy CenterDrug-related rashStevens-Johnson syndromeToxic epidermal necrolysisComprehensive Epilepsy CenterHistory of rashGreatest risk factorEpidermal necrolysisSevere rashEpilepsy centersMedical historyRemote historyRetrospective analysisRashMedication variablesMultivariate analysisPotential predictorsPatientsStrongest predictorPredictorsLTGTitration rateChildren
2004
“Tectonic” hippocampal malformations in patients with temporal lobe epilepsy
Sloviter RS, Kudrimoti HS, Laxer KD, Barbaro NM, Chan S, Hirsch LJ, Goodman RR, Pedley TA. “Tectonic” hippocampal malformations in patients with temporal lobe epilepsy. Epilepsy Research 2004, 59: 123-153. PMID: 15246116, DOI: 10.1016/j.eplepsyres.2004.04.001.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDentate gyrusHippocampal sclerosisFebrile seizuresLobe epilepsyEarly febrile seizuresTypical hippocampal sclerosisNeuronal marker NeuN.Subgroup of patientsAntecedent febrile seizuresTemporal lobe structuresMinor cell lossSubsequent epilepsyNeuronal lossSurgical treatmentHippocampal atrophySynaptic markersHippocampal anomaliesRetrospective analysisEpilepsy patientsHippocampal malformationsPatientsCell lossHippocampusConventional imaging methods