2017
Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy
Chen B, Choi H, Hirsch LJ, Katz A, Legge A, Buchsbaum R, Detyniecki K. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy & Behavior 2017, 76: 24-31. PMID: 28931473, DOI: 10.1016/j.yebeh.2017.08.039.Peer-Reviewed Original ResearchConceptsBehavioral side effectsSide effectsPractice-based sampleAntiepileptic drug useHigh rateAED regimenAdult patientsNewer AEDsCessation ratesAntiepileptic drugsIntractable epilepsyMedical historyAbsence seizuresMedical recordsPhysician reportsAED usePatientsLevetiracetamDepressive moodDrug useGabapentinLamotriginePatient recordsSuicidal thoughtsPhenytoin
2015
Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use
Chen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMore antiepileptic drugsAntiepileptic drugsAbsence seizure typesSpecific antiepileptic drugsAntiepileptic drug useMultiple antiepileptic drugsCertain antiepileptic drugsCognitive effectsHigh rateAED selectionClinical characteristicsIndependent predictorsSeizure typesSingle centerAED loadIndividual patientsPatientsDrug usePhenytoinIntolerabilityAED mechanismsLamotrigineVPAZNS
2008
Patient-reported cognitive side effects of antiepileptic drugs: Predictors and comparison of all commonly used antiepileptic drugs
Arif H, Buchsbaum R, Weintraub D, Pierro J, Resor SR, Hirsch LJ. Patient-reported cognitive side effects of antiepileptic drugs: Predictors and comparison of all commonly used antiepileptic drugs. Epilepsy & Behavior 2008, 14: 202-209. PMID: 19010446, DOI: 10.1016/j.yebeh.2008.10.017.Peer-Reviewed Original ResearchConceptsCognitive side effectsAntiepileptic drugsSide effectsMore antiepileptic drugsWeeks of therapyNonrandomized retrospective studyRetrospective studyMedical recordsAdult outpatientsMultivariate analysisZonisamidePatientsGabapentinLamotrigineDrugsLevetiracetamTopiramateOxcarbazepinePhenytoinCarbamazepinePredictorsMonotherapyOutpatientsEpilepsyTherapyCross-sensitivity of skin rashes with antiepileptic drug use
Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008, 71: 1527-1534. PMID: 18981374, DOI: 10.1212/01.wnl.0000334295.50403.4c.Peer-Reviewed Original ResearchConceptsRate of rashAntiepileptic drugsValproic acidSpecific antiepileptic drugsAntiepileptic drug useMore antiepileptic drugsCertain antiepileptic drugsAED selectionSkin rashIndividual patientsRashPatientsLamotrigineOxcarbazepineDrug usePhenytoinCarbamazepineLevetiracetamZonisamideGabapentinTiagabineVigabatrinClobazamDrugsMedications
2007
The Status of Intravenous Valproate for Status
Hirsch LJ. The Status of Intravenous Valproate for Status. Epilepsy Currents 2007, 7: 96-98. PMID: 17694164, PMCID: PMC1941916, DOI: 10.1111/j.1535-7511.2007.00185.x.Peer-Reviewed Original Research
2005
Effect of Antiepileptic Drug Comedication on Lamotrigine Clearance
Weintraub D, Buchsbaum R, Resor SR, Hirsch LJ. Effect of Antiepileptic Drug Comedication on Lamotrigine Clearance. JAMA Neurology 2005, 62: 1432-1436. PMID: 16157751, DOI: 10.1001/archneur.62.9.1432.Peer-Reviewed Original ResearchConceptsLamotrigine clearanceLamotrigine serum concentrationsNewer AEDsSerum concentrationsColumbia Comprehensive Epilepsy CenterComprehensive Epilepsy CenterLamotrigine monotherapyAdjunctive therapyMedical chartsEpilepsy centersComedicationMonotherapyBody weightPhenytoinValproatePatientsML/hAEDsClearanceSignificant predictorsCarbamazepineOxcarbazepinePredictorsLamotrigineTherapy