2018
Seizure cluster: Definition, prevalence, consequences, and management
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K. Seizure cluster: Definition, prevalence, consequences, and management. Seizure 2018, 68: 9-15. PMID: 29871784, DOI: 10.1016/j.seizure.2018.05.013.Peer-Reviewed Original ResearchConceptsRescue medicationSeizure clustersAcute managementEpilepsy patientsRectal diazepam gelTertiary epilepsy centerEmergency room visitsHealth care utilizationRefractory epilepsy patientsQuality of lifeAcute seizuresBuccal midazolamClinical characteristicsMost patientsCare utilizationEpilepsy centersRoom visitsRisk factorsOnly FDAHigh riskMedicationsPatientsSeizuresPrevalenceCaregivers
2016
Treatment of Convulsive Status Epilepticus
Grover EH, Nazzal Y, Hirsch LJ. Treatment of Convulsive Status Epilepticus. Current Treatment Options In Neurology 2016, 18: 11. PMID: 26920416, DOI: 10.1007/s11940-016-0394-5.Peer-Reviewed Original ResearchAnti-epileptic drugsNon-convulsive SEStatus epilepticusRefractory SEPreferred second-line agentNon-convulsive status epilepticusAnti-seizure medicationsHome rescue medicationThird-line agentsAcute side effectsConvulsive status epilepticusFirst-line treatmentNon-convulsive seizuresSecond-line agentsLower health care costsEmergency room visitsImmuno-modulatory agentsRecovery of consciousnessUse of benzodiazepinesQuality of lifeHealth care costsConsecutive seizuresParaneoplastic etiologyRescue medicationBuccal midazolam
2005
Treatment of convulsive and nonconvulsive status epilepticus
Pang T, Hirsch LJ. Treatment of convulsive and nonconvulsive status epilepticus. Current Treatment Options In Neurology 2005, 7: 247-259. PMID: 15967088, DOI: 10.1007/s11940-005-0035-x.Peer-Reviewed Original ResearchContinuous intravenous midazolamOpinion statementStatus epilepticusNonconvulsive status epilepticusDrug of choiceRectal benzodiazepinesBuccal midazolamIntravenous midazolamProlonged seizuresRisk patientsIntravenous accessPrehospital treatmentStatus epilepticusHospital protocolInitial treatmentRandomized trialsRectal diazepamMental statusPoor responseWorse outcomesFull dosesBest treatmentEpilepticusTreatmentPatientsMidazolam