2020
Aging exacerbates neutrophil pathogenicity in ischemic stroke
Roy-O'Reilly MA, Ahnstedt H, Spychala MS, Munshi Y, Aronowski J, Sansing LH, McCullough LD. Aging exacerbates neutrophil pathogenicity in ischemic stroke. Aging 2020, 12: 436-461. PMID: 31927534, PMCID: PMC6977697, DOI: 10.18632/aging.102632.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeNeutrophil-activating cytokineStroke patientsNeutrophil functionNeutrophil reactive oxygen speciesPoor post-stroke outcomesDepletion of neutrophilsPro-inflammatory functionsStrong risk factorExperimental mouse modelPost-stroke outcomesHigher stroke mortalityStroke outcomePoor outcomeFunctional outcomeStroke mortalityLong-term benefitsRisk factorsSpecific monoclonal antibodiesNeutrophil trafficTissue injuryYoung miceAged subjectsMouse model
2019
Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage
Chang CF, Massey J, Osherov A, Angenendt da Costa LH, Sansing LH. Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage. Stroke 2019, 51: 612-618. PMID: 31826730, PMCID: PMC7135897, DOI: 10.1161/strokeaha.119.027037.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageBexarotene treatmentFunctional recoveryHematoma clearanceRetinoid X receptor agonistExperimental intracerebral hemorrhageX receptor agonistMacrophage TNF productionMarrow-derived macrophagesNeurological recoveryNeurobehavioral recoveryNeurological deficitsAutologous bloodBrain recoveryHematoma volumeReceptor agonistTherapeutic effectMacrophage expressionTNF productionMouse modelVivo phagocytosisMacrophage phenotypeFlow cytometryHistological analysisErythrocyte metabolites