Laura Niklason, PhD, MD
Professor AdjunctCards
About
Research
Overview
Currently, Dr. Niklason's research program has several areas of focus. With regard to engineered arteries. Niklason is engaged in preclinical studies in large animals to validate the method for generating engineered tissues that are available "off the shelf". Large animal studies on vascular grafts are centered on immune/inflammatory response minimization to these off-the-shelf tissues, and on the long-term function of the grafts in the arterial circulation. In addition, Niklason is developing tissue engineering approaches to generating vascularized cardiac muscle, as well as vascularized lung tissue. In addition, Niklason has active research interests in vascular remodeling that is associated with various disease states, including atherosclerosis and arterial vaso spasm.
- Tissue engineered arteries, utilizing decellularization approaches
- Regeneration of whole, functional lung tissue
- Engineering of thoracic conduits, including trachea and esophagus
- Investigation of the molecular basis of cellular aging in various tissues
- Investigation of causes of intimal hyperplasia in vein grafts
Medical Subject Headings (MeSH)
Anesthesiology; Biomedical Engineering; Biophysics; Blood Vessels; Lung; Physics; Tissue Engineering
Academic Achievements & Community Involvement
News & Links
News
- May 19, 2022
A Celebration of Student Research and Faculty Mentorship
- November 15, 2021
Yale Investigators Form Team to Develop Therapies for Devastating Kidney Disease
- September 29, 2020
Yale Department of Anesthesiology 5th Annual Celebration of Research 2020
- April 16, 2020
Sharing a Ventilator, Sparing a Life: Two Yale Groups Create Different Ways To Maximize Ventilator Capacity in a Crisis