Laura Niklason, PhD, MD
Professor AdjunctDownloadHi-Res Photo
Cards
Appointments
Anesthesiology
Primary
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
Appointments
Anesthesiology
Primary
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
Appointments
Anesthesiology
Primary
Additional Titles
Division Chief
Vice Chair, Research
Contact Info
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States
About
Titles
Professor Adjunct
Division Chief; Vice Chair, Research
Biography
Dr. Niklason is the Nicholas M. Greene Professor at Yale University in Anesthesia and Biomedical Engineering, where she has been on faculty since 2006. Dr. Niklason’s research focuses primarily on regenerative strategies for cardiovascular and lung tissues. Niklason’s engineered blood vessels are currently in clinical trials, and are the first life-sustaining engineered tissue to be studied in any Phase III trial. Niklason’s lab was also one of the first to describe the engineering of whole lung tissue that could exchange gas in vivo, and this work was cited in 2010 as one of the top 50 most important inventions of the year by Time Magazine. She was inducted into the National Academy of Inventors in 2014, and was elected to the National Academy of Medicine in 2015.
Niklason received her PhD in Biophysics from the University of Chicago, and her MD from the University of Michigan. She completed her residency training in anesthesia and intensive care unit medicine at the Massachusetts General Hospital in Boston, and completed post-doctoral scientific training at Massachusetts Institute of Technology.
Appointments
Anesthesiology
Professor AdjunctPrimary
Other Departments & Organizations
- Anesthesiology
- NIH T32 Program
- Niklason Lab
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Fellow
- Mass General Hospital (1996)
- Resident
- Mass General Hospital (1995)
- Intern
- University of Michigan (1992)
- MD
- University of Michigan/Ann Arbor (1991)
- PhD
- University of Chicago (1988)
Board Certifications
Critical Care Medicine Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1999
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1998
Research
Overview
Currently, Dr. Niklason's research program has several areas of focus. With regard to engineered arteries. Niklason is engaged in preclinical studies in large animals to validate the method for generating engineered tissues that are available "off the shelf". Large animal studies on vascular grafts are centered on immune/inflammatory response minimization to these off-the-shelf tissues, and on the long-term function of the grafts in the arterial circulation. In addition, Niklason is developing tissue engineering approaches to generating vascularized cardiac muscle, as well as vascularized lung tissue. In addition, Niklason has active research interests in vascular remodeling that is associated with various disease states, including atherosclerosis and arterial vaso spasm.
- Tissue engineered arteries, utilizing decellularization approaches
- Regeneration of whole, functional lung tissue
- Engineering of thoracic conduits, including trachea and esophagus
- Investigation of the molecular basis of cellular aging in various tissues
- Investigation of causes of intimal hyperplasia in vein grafts
Medical Subject Headings (MeSH)
Anesthesiology; Biomedical Engineering; Biophysics; Blood Vessels; Lung; Physics; Tissue Engineering
- View Lab Website
Niklason Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Laura Niklason's published research.
Publications Timeline
A big-picture view of Laura Niklason's research output by year.
Research Interests
Research topics Laura Niklason is interested in exploring.
Liping Zhao, MS, HT (ASCP)
Micha Sam Brickman Raredon, MD, PhD
Dianqing (Dan) Wu, PhD
Farida Ahangari, MD
Johad Khoury
Naftali Kaminski, MD
23Publications
3,061Citations
Tissue Engineering
Lung
Blood Vessels
Publications
2024
Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regression335-OR: Preliminary Results of Islet Survival in a Novel Biovascular Pancreas Implanted in Primates
KURAL M, NASH K, NAEGELI K, QIAN H, WANG J, KIRKTON R, NIKLASON L. 335-OR: Preliminary Results of Islet Survival in a Novel Biovascular Pancreas Implanted in Primates. Diabetes 2024, 73 DOI: 10.2337/db24-335-or.Peer-Reviewed Original ResearchSingle-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original Research
2021
Five-Year Outcome in Patients with ESRD Who Received the Bioengineered Human Acellular Vessel for Dialysis Access
Lawson J, Niklason L, Pilgrim A, Kirkton R, Prichard H. Five-Year Outcome in Patients with ESRD Who Received the Bioengineered Human Acellular Vessel for Dialysis Access. Journal Of The American Society Of Nephrology 2021, 32: 232-232. DOI: 10.1681/asn.20213210s1232b.Peer-Reviewed Original Research
2016
Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices
Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE. Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices. Acta Biomaterialia 2016, 46: 91-100. PMID: 27693690, PMCID: PMC5451113, DOI: 10.1016/j.actbio.2016.09.043.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular matrixLung extracellular matrixMatrix proteinsECM-associated proteinsCell-matrix interactionsProtein extraction methodsWhole organ regenerationRegenerative medicineOrganotypic cell culturesQuantitative proteomicsAcellular extracellular matrixECM proteinsOrgan regenerationCell adhesionProteomicsProtein analysisQuantitative biochemical dataProteinPotent substrateXenogeneic extracellular matrixTargeted proteomicsCell nuclear antigenBiochemical dataImportant glycoproteinCell culturesEngineered Tissue–Stent Biocomposites as Tracheal Replacements
Zhao L, Sundaram S, Le AV, Huang AH, Zhang J, Hatachi G, Beloiartsev A, Caty MG, Yi T, Leiby K, Gard A, Kural MH, Gui L, Rocco KA, Sivarapatna A, Calle E, Greaney A, Urbani L, Maghsoudlou P, Burns A, DeCoppi P, Niklason LE. Engineered Tissue–Stent Biocomposites as Tracheal Replacements. Tissue Engineering Part A 2016, 22: 1086-1097. PMID: 27520928, PMCID: PMC5312617, DOI: 10.1089/ten.tea.2016.0132.Peer-Reviewed Original ResearchCitationsAltmetricImpaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice
Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice. Blood 2016, 128: 1642-1650. PMID: 27471233, PMCID: PMC5034742, DOI: 10.1182/blood-2016-03-702845.Peer-Reviewed Original ResearchCitationsAltmetricNew Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx
Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE. New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36: 1847-1853. PMID: 27386939, PMCID: PMC5283952, DOI: 10.1161/atvbaha.116.308023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntithrombinsAorta, ThoracicBiological AssayBlood CoagulationCells, CulturedChromatography, LiquidFactor XaGlycocalyxHeparinHeparitin SulfateHuman Umbilical Vein Endothelial CellsMaleMass SpectrometryMicroscopy, Electron, TransmissionRats, Sprague-DawleyReproducibility of ResultsThrombinTime FactorsConceptsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsVein endothelial cellsNative aortaEndothelial cellsHuman umbilical vein endothelial cell monolayersCultured human umbilical vein endothelial cellsFactor XaVascular healthEndothelial cell monolayersVascular diseaseRat aortaDamaged vasculatureAnticoagulant capacityVascular communityAortaTherapeutic developmentActivity assessmentCell monolayersVascular graftsLiquid chromatography-mass spectrometry analysisNovel assayGlycocalyxAssaysNative rat aortaComparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine
Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials 2016, 102: 220-230. PMID: 27344365, PMCID: PMC4939101, DOI: 10.1016/j.biomaterials.2016.06.025.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman endothelial cellsCell-matrix interactionsLung regenerationEndothelial cellsKey matrix proteinsComparative biologyCell adhesion moleculeMatrix proteinsLung extracellular matrixCell healthExtracellular matrixResidual DNASpecies mismatchRat lung scaffoldsRegenerative medicineAdhesion moleculesLung scaffoldsPrimate tissuesCellsVascular cell adhesion moleculeLung engineeringLung matrixLess expressionPulmonary cellsProfound effect
Academic Achievements & Community Involvement
activity Stem Cell Research
ResearchDetails01/01/2007 - PresentUnited KingdomAbstract/SynopsisProfessor Niklason collaborates with Dr. Sanjay Sinha and Dr. Roger Pedersen of Cambridge University. Their work centers on stem cell research.
News & Links
News
- May 19, 2022
A Celebration of Student Research and Faculty Mentorship
- November 15, 2021
Yale Investigators Form Team to Develop Therapies for Devastating Kidney Disease
- September 29, 2020
Yale Department of Anesthesiology 5th Annual Celebration of Research 2020
- April 16, 2020
Sharing a Ventilator, Sparing a Life: Two Yale Groups Create Different Ways To Maximize Ventilator Capacity in a Crisis
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Mailing Address
Anesthesiology
PO Box 208089, 10 Amistad Street, Room 301D
New Haven, CT 06520-8089
United States