2019
Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration
Szigeti‐Buck K, Manuelidis L. Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration. Journal Of Cellular Biochemistry 2019, 120: 17687-17698. PMID: 31231867, DOI: 10.1002/jcb.29035.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseGuinea pigsMammalian brainSporadic Creutzfeldt-Jakob diseaseOnly excitatory neuronsHippocampal pyramidal neuronsGranule cell layerInternal granule cell layerPancreatic islet cellsPyramidal neuronsSporadic CJDHidden infectionType synapsesExcitatory synapsesExcitatory neuronsMossy fibersPurkinje neuronsProgressive neurodegenerationNeuron synapsesIslet cellsSpecific neuronsWestern blotNeuronsPancreatic exocrine cellsKidney tubules
2018
Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells
Manuelidis L. Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells. Journal Of Cellular Biochemistry 2018, 120: 6198-6208. PMID: 30317668, DOI: 10.1002/jcb.27907.Peer-Reviewed Original ResearchConceptsOpen reading frameReplication initiation sequencesTissue-specific patternsHuman germline cellsSmall circular DNAREP peptidesGermline cellsMaternal inheritanceRep proteinSomatic cellsReading frameCell communicationEnvironmental infectious agentsMature spermDifferentiation functionPhage virusesCultured cellsCircular DNAInitiation sequenceSymbiotic elementsExocrine cellsFunctional differentiationSpinal cord synapsesMammalian brainDNA