2016
CJD and Scrapie Require Agent‐Associated Nucleic Acids for Infection
Botsios S, Manuelidis L. CJD and Scrapie Require Agent‐Associated Nucleic Acids for Infection. Journal Of Cellular Biochemistry 2016, 117: 1947-1958. PMID: 26773845, DOI: 10.1002/jcb.25495.Peer-Reviewed Original ResearchConceptsTSE agentsTransmissible spongiform encephalopathiesAdaptive immune responsesDegenerative brain changesInfectious particlesHost prion proteinGT1 neuronal cellsForms of PrPLymphoreticular tissuesBrain changesImmune responseTSE strainsNeuronal cellsNeurodegenerative diseasesLatent virusInfectivity assaysSpongiform encephalopathiesNucleic acid genomeTitersEpidemic spreadViral structuresPrion proteinHost proteinsVirusHost components
2015
Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt‐Jakob disease
Kipkorir T, Colangelo CM, Manuelidis L. Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt‐Jakob disease. Proteomics 2015, 15: 2983-2998. PMID: 25930988, PMCID: PMC4601564, DOI: 10.1002/pmic.201500059.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseInfectious agentsTransmissible encephalopathiesNew therapeutic initiativesBrain particlesCausal infectious agentInfectious particlesHost prion proteinHost immune recognitionSynapsin-2Such therapyHost proteinsTherapeutic initiativesImmune recognitionStrain-specific patternsCommon pathwayCross-species transmissionHigh infectivityDiseaseViral pathwaysProteomic analysisHost targetsViral proteinsViral processingBrain components