2014
Highly Infectious CJD Particles Lack Prion Protein but Contain Many Viral‐Linked Peptides by LC‐MS/MS
Kipkorir T, Tittman S, Botsios S, Manuelidis L. Highly Infectious CJD Particles Lack Prion Protein but Contain Many Viral‐Linked Peptides by LC‐MS/MS. Journal Of Cellular Biochemistry 2014, 115: 2012-2021. PMID: 24933657, PMCID: PMC7166504, DOI: 10.1002/jcb.24873.Peer-Reviewed Original ResearchConceptsSporadic CJDMouse brainTransmissible encephalopathiesNormal human brain samplesHost prion proteinHuman brain samplesSCJD brainsPrion proteinAmyloid pathologyAPP processingNew therapiesUninfected controlsBrain homogenatesBrain samplesCellular findingsDetectable PrPNeurodegenerative diseasesSheep scrapieInfectious titerBrainProteinase KCJDLC-MS/MSViral motifsInfectious form
2011
High CJD infectivity remains after prion protein is destroyed
Miyazawa K, Emmerling K, Manuelidis L. High CJD infectivity remains after prion protein is destroyed. Journal Of Cellular Biochemistry 2011, 112: 3630-3637. PMID: 21793041, PMCID: PMC3202053, DOI: 10.1002/jcb.23286.Peer-Reviewed Original ResearchConceptsTransmissible spongiform encephalopathy agentsSpongiform encephalopathy agentInfectious particlesHost prion proteinPK digestionTotal PrPCJD infectivityInfectious homogenatesPrion proteinBrain resultsHigh titersTitersCell infectivityCell-based assaysCell culture assaysInfectivityProteinase K treatmentInfectious formPrPBrainCulture assaysAssaysProteinSensitive formK treatment
2001
Blood borne transit of CJD from brain to gut at early stages of infection
Radebold K, Chernyak M, Martin D, Manuelidis L. Blood borne transit of CJD from brain to gut at early stages of infection. BMC Infectious Diseases 2001, 1: 20. PMID: 11716790, PMCID: PMC59894, DOI: 10.1186/1471-2334-1-20.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseIC inoculationAbnormal PrPCJD agentTransmissible spongiform encephalopathiesLymphoreticular tissuesEnteric infectionsIp inoculationPrP accumulationSpinal cordPeripheral tissuesGastrointestinal tractInfectious inoculumLymphatic drainageInfectious agentsVascular routeCell infectivityInfectionTerminal stageDiseaseSpongiform encephalopathiesDifferent organsBrainDaysProgressive appearance
1986
IMMORTALITY AND TUMORGENICITY OF TISSUE CULTURE LINES DERIVED FROM CREUTZFELDT-JAKOB BRAINS OF HAMSTERS AND MICE
Manuelidis E, Kim J, Manuelidis L. IMMORTALITY AND TUMORGENICITY OF TISSUE CULTURE LINES DERIVED FROM CREUTZFELDT-JAKOB BRAINS OF HAMSTERS AND MICE. Journal Of Neuropathology & Experimental Neurology 1986, 45: 325. DOI: 10.1097/00005072-198605000-00038.Peer-Reviewed Original Research
1982
SEQUENTIAL MORPHOLOGIC CHANGES IN THE BRAIN OF GUINEA PIGS WITH EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE
Kim J, Manuelidis L, Manuelidis E. SEQUENTIAL MORPHOLOGIC CHANGES IN THE BRAIN OF GUINEA PIGS WITH EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1982, 41: 364. DOI: 10.1097/00005072-198205000-00081.Peer-Reviewed Original Research