Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS
Dobbyn A, Huckins L, Boocock J, Sloofman L, Glicksberg B, Giambartolomei C, Hoffman G, Perumal T, Girdhar K, Jiang Y, Raj T, Ruderfer D, Kramer R, Pinto D, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl E, Sieberts S, Sklar P, Buxbaum J, Devlin B, Lewis D, Gur R, Hahn C, Hirai K, Toyoshiba H, Domenici E, Essioux L, Mangravite L, Peters M, Lehner T, Lipska B, Cicek A, Lu C, Roeder K, Xie L, Talbot K, Hemby S, Essioux L, Browne A, Chess A, Topol A, Charney A, Dobbyn A, Readhead B, Zhang B, Pinto D, Bennett D, Kavanagh D, Ruderfer D, Stahl E, Schadt E, Hoffman G, Shah H, Zhu J, Johnson J, Fullard J, Dudley J, Girdhar K, Brennand K, Sloofman L, Huckins L, Fromer M, Mahajan M, Roussos P, Akbarian S, Purcell S, Hamamsy T, Raj T, Haroutunian V, Wang Y, Gümüş Z, Senthil G, Kramer R, Logsdon B, Derry J, Dang K, Sieberts S, Perumal T, Visintainer R, Shinobu L, Sullivan P, Klei L. Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. American Journal Of Human Genetics 2018, 102: 1169-1184. PMID: 29805045, PMCID: PMC5993513, DOI: 10.1016/j.ajhg.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedEpigenesis, GeneticGenome, HumanGenome-Wide Association StudyHumansPrefrontal CortexQuantitative Trait LociSchizophreniaConceptsExpression quantitative trait lociConditional expression quantitative trait lociCommonMind ConsortiumEQTL signalsGenome-wide association study (GWAS) lociSchizophrenia GWASContext-specific regulationQuantitative trait lociCo-localization analysisGene expression levelsGWAS associationsNovel genesTrait lociStudy lociCausal genesEQTL dataFine mappingGenomic featuresGWAS statisticsGene expressionGenesGWASLociExpression levelsHuman brain samplesRecent Genetics and Epigenetics Approaches to PTSD
Daskalakis N, Rijal C, King C, Huckins L, Ressler K. Recent Genetics and Epigenetics Approaches to PTSD. Current Psychiatry Reports 2018, 20: 30. PMID: 29623448, PMCID: PMC6486832, DOI: 10.1007/s11920-018-0898-7.Peer-Reviewed Original ResearchMeSH KeywordsEpigenesis, GeneticEpigenomicsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderTrauma exposureGenome-wide association studiesEpigenetic approachesTargeted genetic studiesEpigenome-wide studiesInduce epigenetic changesResponse to trauma exposureAssociation studiesAdult trauma exposureGenetic studiesNegative emotional symptomsEpigenetic alterationsEpigenetic changesFunctional regulationEpigenetic riskIntrusive memoriesStress disorderTraumatic exposureImpaired cognitionEmotional symptomsAvoidance behaviorDisability syndromeBiological riskElectronic medical records