2022
Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits
Lencz T, Sabatello M, Docherty A, Peterson R, Soda T, Austin J, Bierut L, Crepaz-Keay D, Curtis D, Degenhardt F, Huckins L, Lazaro-Munoz G, Mattheisen M, Meiser B, Peay H, Rietschel M, Walss-Bass C, Davis L. Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits. The Lancet Psychiatry 2022, 9: 838-844. PMID: 35931093, PMCID: PMC9930635, DOI: 10.1016/s2215-0366(22)00157-2.Peer-Reviewed Original ResearchConceptsRisk of complex diseasesPolygenic risk scoresEthical issuesEthical implicationsPersonal viewEmbryo screeningGenetic riskRisk scorePolygenic embryo screeningPsychiatric geneticsInternational Society of Psychiatric GeneticsComplex diseasesViewsPsychiatric disordersRelevant stakeholdersScreeningIn vitro fertilisationScreen embryosInternational SocietyPersonsPrivate companiesSocietyClinical application
2019
International Society of Psychiatric Genetics Ethics Committee: Issues facing us
Lázaro‐Muñoz G, Sabatello M, Huckins L, Peay H, Degenhardt F, Meiser B, Lencz T, Soda T, Docherty A, Crepaz‐Keay D, Austin J, Peterson R, Davis L, Committee O. International Society of Psychiatric Genetics Ethics Committee: Issues facing us. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 543-554. PMID: 31124312, PMCID: PMC6861601, DOI: 10.1002/ajmg.b.32736.Peer-Reviewed Original ResearchConceptsInternational Society of Psychiatric GeneticsPsychiatric geneticsPsychiatric genetic researchGenetic researchELSI challengesGenetic counselorsClinical geneticistsEthics CommitteeGeneticsELSI issuesMental health professionalsLegal proceedingsClinical settingPatientsInternational organizationsEthical translationMental illnessInternational reachInternational SocietyBiological underpinningsGeneticistsELSIIncreased awarenessPsychiatric researchHealth professionals