Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov
Bothwell LE, Avorn J, Khan NF, Kesselheim AS. Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov. BMJ Open 2018, 8: e018320. PMID: 29440155, PMCID: PMC5829673, DOI: 10.1136/bmjopen-2017-018320.Peer-Reviewed Original ResearchConceptsIndependent data monitoring committeeData monitoring committeeDesign clinical trialEuropean Medicines AgencyClinical trialsInterim analysisAdaptive design clinical trialsPhase I/II trialPhase II/IIIAdaptive trialsControlled Clinical TrialsBasic study characteristicsWeb of ScienceII trialCochrane RegistryInclusion criteriaDose-finding designDrug AdministrationMedicines AgencyStudy characteristicsSuch trialsMonitoring committeeAdaptive design featuresPhase ITrials