2013
Reproducibility of research and preclinical validation: problems and solutions
Pusztai L, Hatzis C, Andre F. Reproducibility of research and preclinical validation: problems and solutions. Nature Reviews Clinical Oncology 2013, 10: 720-724. PMID: 24080600, DOI: 10.1038/nrclinonc.2013.171.Peer-Reviewed Original ResearchBiomedical ResearchDrug Evaluation, PreclinicalHumansReproducibility of ResultsValidation Studies as Topic
2010
The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches
Lacerda L, Pusztai L, Woodward WA. The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches. Drug Resistance Updates 2010, 13: 99-108. PMID: 20739212, DOI: 10.1016/j.drup.2010.08.001.Peer-Reviewed Original ResearchConceptsTumor initiating cellsInitiating cellsCancer cellsLong-term outcomesBreast cancer recurrenceFuture therapeutic approachesTumor-stromal interactionsBreast cancer cellsHedgehog inhibitor cyclopamineNeoadjuvant chemotherapyResidual diseaseEffective therapyCancer recurrenceBreast cancerTherapeutic approachesInhibitor lapatinibInhibitor cyclopamineTherapy resistanceRegulation of tumorChemical library screenDrug resistanceChemotherapy-resistant subpopulationMultidrug resistanceNovel targetResistant subpopulations