2022
Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm
O'Neill KE, Maher JY, Laronda MM, Duncan FE, LeDuc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL, Zelinski MB, Halvorson LM, Gomez-Lobo V. Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm. American Journal Of Obstetrics And Gynecology 2022, 228: 270-275.e4. PMID: 36191605, PMCID: PMC9974561, DOI: 10.1016/j.ajog.2022.09.040.Peer-Reviewed Original ResearchLaparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderImpact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal?
Oktay K, Marin L, Titus S. Impact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal? Fertility And Sterility 2022, 117: 396-398. PMID: 34998576, DOI: 10.1016/j.fertnstert.2021.12.007.Peer-Reviewed Original Research
2021
Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data
Oktay K, Marin L, Bedoschi G, Pacheco F, Sugishita Y, Kawahara T, Taylan E, Acosta C, Bang H. Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data. Fertility And Sterility 2021, 117: 181-192. PMID: 34801235, PMCID: PMC8863399, DOI: 10.1016/j.fertnstert.2021.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesCryopreservationExtracellular MatrixFemaleFertility PreservationHumansMeta-Analysis as TopicNeovascularization, PhysiologicOvaryPregnancyPregnancy RateRetrospective StudiesRobotic Surgical ProceduresTissue Culture TechniquesTissue ScaffoldsTransplantation, AutologousYoung AdultConceptsGraft longevityCase seriesOvarian functionLow-dose aspirinOvarian tissue transplantationOvarian cortical piecesLower embryo qualityOocytes/embryosNeonatal outcomesTransdermal estrogenChemotherapy exposureOvarian transplantationCortical piecesMeta-analytic dataLower abdomenHealthy childrenLive birthsMAIN OUTCOMEGraft vascularizationExtracellular matrix scaffoldsOvarian tissueAneuploidy rateFunction returnsEmbryo qualityMeta-analytic updateComparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezingAssociation of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data
Turan V, Lambertini M, Lee D, Wang E, Clatot F, Karlan B, Demeestere I, Bang H, Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. Journal Of Clinical Oncology 2021, 39: 2016-2024. PMID: 33891474, PMCID: PMC8260903, DOI: 10.1200/jco.20.02880.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataSerum AMH levelsDiminished ovarian reservePatient-level dataAMH levelsOvarian reservePathogenic variantsGermline BRCA pathogenic variantLow serum AMH levelsAnti-Müllerian hormone levelsOral contraceptive pill useLower AMH levelsDecreased ovarian reserveBody mass indexContraceptive pill useBRCA pathogenic variantsEvaluable womenMass indexMean ageHormone levelsBreast cancerAffected womenPill useMeta-AnalysisYoung womenDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantationIndividual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation
Titus S, Szymanska K, Musul B, Turan V, Taylan E, Garcia- Milian R, Mehta S, Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Scientific Reports 2021, 11: 407. PMID: 33431979, PMCID: PMC7801500, DOI: 10.1038/s41598-020-79643-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCyclophosphamideDNA DamageFemaleGene Expression ProfilingHeterograftsHumansMiceMice, Inbred NODMice, SCIDOocytesOogenesisOvarian FollicleOvarian ReserveOvarySignal TransductionSingle-Cell AnalysisTranscriptomeYoung AdultConceptsPrimordial follicle oocytesFollicle lossGrowth activationHuman ovarian xenograft modelPI3K/PTEN/AktFollicle oocytesDNA damagePI3K/PTEN/Akt pathwayOvarian reserve depletionPrimordial follicle reservePTEN/AKT pathwayIngenuity Pathway AnalysisOvarian xenograft modelPTEN/AKTSevere DNA damageExpression of AktGonadotoxic chemotherapyAnti-apoptotic Bcl2Early menopauseFollicle reserveTranscriptomic analysisCyclophosphamide injectionHuman ovaryPhosphorylation statusRNA sequencing
2020
Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
Goldfarb S, Turan V, Bedoschi G, Taylan E, Abdo N, Cigler T, Bang H, Patil S, Dickler M, Oktay K. Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer. Breast Cancer Research And Treatment 2020, 185: 165-173. PMID: 32930927, PMCID: PMC7877450, DOI: 10.1007/s10549-020-05933-7.Peer-Reviewed Original ResearchConceptsAnti-Mullerian hormoneOvarian reserveAdjuvant chemotherapyBreast cancerAMH levelsChemotherapy regimensCompletion of ACSerum AMH levelsAdjuvant tamoxifenAMH recoveryChemotherapy groupPrimary diagnosisBaseline ageMethodsOne hundredAMH assessmentRegimensChemotherapyYoung womenTamoxifenSignificant recoveryCancerMixed effects modelsMonthsTreatment effectsWomenUnraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivationExpert Commentary on Fertility Preservation in Colorectal Cancers: Current State and Practical Tips for the Cancer Practitioner.
Oktay K. Expert Commentary on Fertility Preservation in Colorectal Cancers: Current State and Practical Tips for the Cancer Practitioner. Diseases Of The Colon & Rectum 2020, 63: 726-727. PMID: 32384403, DOI: 10.1097/dcr.0000000000001688.Peer-Reviewed Original Research
2019
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
Turan V, Oktay K. BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. Human Reproduction Update 2019, 26: 43-57. PMID: 31822904, PMCID: PMC6935693, DOI: 10.1093/humupd/dmz043.Peer-Reviewed Original ResearchFertility preservation in gynecologic cancers
Taylan E, Oktay K. Fertility preservation in gynecologic cancers. Gynecologic Oncology 2019, 155: 522-529. PMID: 31604663, DOI: 10.1016/j.ygyno.2019.09.012.Peer-Reviewed Original ResearchConceptsFertility preservationGynecologic cancerFertility-sparing surgical approachCancer survivorship careReproductive-age womenGynecologic malignanciesSurvivorship careSurgical approachTreatment optionsAge womenOvarian cancerNumber of womenCancerWomenReproductive technologiesSignificant proportionCurrent knowledgeReview articleMalignancyReproductive potentialCareAdvances in fertility-preservation surgery: navigating new frontiers
Christianson M, Oktay K. Advances in fertility-preservation surgery: navigating new frontiers. Fertility And Sterility 2019, 112: 438-445. PMID: 31446903, DOI: 10.1016/j.fertnstert.2019.06.029.Peer-Reviewed Original ResearchConceptsFertility preservation surgeryFertility preservationSurgical optionsVital reproductive organFertility-preserving surgeryUterine fixationRadical trachelectomyGynecologic malignanciesFemale patientsFirst transplantationCancer patientsReproductive organsFuture fertilityReproductive surgeryMedical conditionsTransposition procedureSelect cancersSurgerySurgical creativityTissue 20PatientsMajor advancesOrgansTrachelectomyTransplantationFertility preservation in girls with Turner syndrome: limitations, current success and future prospects
Oktay K, Bedoschi G. Fertility preservation in girls with Turner syndrome: limitations, current success and future prospects. Fertility And Sterility 2019, 111: 1124-1126. PMID: 31056311, DOI: 10.1016/j.fertnstert.2019.03.018.Peer-Reviewed Original Research
2013
Fertility preservation options in women with endometriosis.
Bedoschi G, Turan V, Oktay K. Fertility preservation options in women with endometriosis. Minerva Obstetrics And Gynecology 2013, 65: 99-103. PMID: 23598777.Peer-Reviewed Original ResearchConceptsReproductive-age womenSuppressive medical therapyFertility preservation optionsFertility preservation proceduresFertility preservation techniquesLow ovarian reserveNormal ovarian tissuesMore effective treatmentsEndometrioma wallIncidental excisionPelvic painUntreated womenOvarian reserveInfertile womenMedical therapyOvarian endometriomaSevere endometriosisSurgical treatmentAge womenChronic conditionsEndometriosis progressionPreservation optionsEffective treatmentEndometriosisImpaired fertility
2012
Ovarian cryopreservation.
Jeong K, Aslan E, Ozkaya E, Sonmezer M, Oktay K. Ovarian cryopreservation. Minerva Medica 2012, 103: 37-46. PMID: 22278067.Peer-Reviewed Original ResearchConceptsFertility preservationOvarian tissueNon-malignant diseasesFuture autotransplantationOvarian cryopreservationOvarian failurePrepubertal girlsReproductive endocrinologistsMalignant cellsTeam approachWhole ovariesHeterotopic locationNew promising strategyAutotransplantationSignificant delayDiseaseTissue piecesTissuePromising strategySlow freezingChemotherapyLaparoscopyPatientsEndocrinologistsOncologists
2010
In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation
Oktay K, Buyuk E, Rodriguez-Wallberg K, Sahin G. In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation. Reproductive BioMedicine Online 2010, 20: 634-638. PMID: 20219430, DOI: 10.1016/j.rbmo.2010.01.012.Peer-Reviewed Original ResearchConceptsBreast cancer patientsMature oocyte yieldCancer patientsOvarian stimulationOocyte yieldFertility preservationFertility preservation cyclesMature oocytesCryopreservation cyclesTotal numberSecondary analysisVitro maturationImmature oocytesPatientsIVMEmbryo cryopreservationFertilization rateOocytesStimulationUseful strategyMaturationChemotherapy
2009
Fertility Preservation for Breast Cancer Patients
Oktem O, Oktay K. Fertility Preservation for Breast Cancer Patients. Seminars In Reproductive Medicine 2009, 27: 486-492. PMID: 19806518, DOI: 10.1055/s-0029-1241059.Peer-Reviewed Original ResearchConceptsBreast cancer patientsOvarian stimulation protocolsCancer patientsBreast cancerFertility preservationCancer survivorsStimulation protocolConventional ovarian stimulation protocolsRise of estrogenOvarian tissue freezingBreast cancer survivorsPreservation of fertilityEndogenous estrogen levelsFertility preservation strategiesAromatase inhibitor letrozolePremature ovarian failureNew cancer casesAdjuvant chemotherapyOvarian stimulationFertilization cyclesEstrogen levelsOvarian failureOocyte freezingReproductive ageCommon neoplasmStem cells and reproductive medicine.
Oktem O, Oktay K. Stem cells and reproductive medicine. Minerva Obstetrics And Gynecology 2009, 61: 247-52. PMID: 19745792.Peer-Reviewed Original Research