2008
c-Jun N-terminal kinase (JNK) pathway controls granulosa cell mitosis: a novel mechanism in regulation of preantral follicle growth
Oktem O, Oktay K. c-Jun N-terminal kinase (JNK) pathway controls granulosa cell mitosis: a novel mechanism in regulation of preantral follicle growth. Fertility And Sterility 2008, 90: s330. DOI: 10.1016/j.fertnstert.2008.07.1663.Peer-Reviewed Original Research
2005
Role of Extracellular Matrix, Activin-A and Mitogen Activated Protein Kinase (MAPK) Signaling Pathways in Preantral Follicle Growth and Survival in the Mouse
Oktem O, Oktay K. Role of Extracellular Matrix, Activin-A and Mitogen Activated Protein Kinase (MAPK) Signaling Pathways in Preantral Follicle Growth and Survival in the Mouse. Fertility And Sterility 2005, 84: s384-s385. DOI: 10.1016/j.fertnstert.2005.07.1007.Peer-Reviewed Original Research
2003
Deciphering early folliculogenesis: Jun Amino Terminal Kinase (JNK) plays a key role in preantral follicle growth
Oktay K, Buyuk E, Oktem O, Oktay M, Rosenwaks Z, Giancotti F. Deciphering early folliculogenesis: Jun Amino Terminal Kinase (JNK) plays a key role in preantral follicle growth. Fertility And Sterility 2003, 80: 26-27. DOI: 10.1016/s0015-0282(03)01871-5.Peer-Reviewed Original Research
2000
Interaction of Extracellular Matrix and Activin-A in the Initiation of Follicle Growth in the Mouse Ovary1
Oktay K, Karlikaya G, Akman O, Ojakian G, Oktay M. Interaction of Extracellular Matrix and Activin-A in the Initiation of Follicle Growth in the Mouse Ovary1. Biology Of Reproduction 2000, 63: 457-461. PMID: 10906050, DOI: 10.1095/biolreprod63.2.457.Peer-Reviewed Original ResearchConceptsFollicle growth initiationFollicle developmentFollicle growthFollicle growth rateFollicle densityRecombinant human activinEarly follicle developmentEarly follicular developmentRole of activinAbsence of activinTotal folliclesFollicular growthExtracellular matrixFollicular developmentTreatment groupsMultilayer folliclesMouse ovariesActivin treatmentHuman activinPresence of lamininActivinExtracellular matrix componentsPrecise mechanismMiceFolliclesNew Strategies in Studying Ovarian Aging
Oktay K, Karlikaya G, Bayrakceken A. New Strategies in Studying Ovarian Aging. Serono Symposia USA 2000, 80-88. DOI: 10.1007/978-0-387-21628-7_8.Peer-Reviewed Original Research
1998
Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone.
Oktay K, Newton H, Mullan J, Gosden R. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Human Reproduction 1998, 13: 1133-1138. PMID: 9647533, DOI: 10.1093/humrep/13.5.1133.Peer-Reviewed Original ResearchConceptsWeeks of graftingSevere combined immunodeficiencyFollicle growthOvarian xenograftsAntral stageOestradiol levelsLong-term graftHuman ovarian xenograftsHuman follicle developmentHuman ovarian tissueOvarian follicular growthPreantral follicle growthLong-term graftingGranulosa cell layerHuman primordial folliclesCell nuclear antigenFSH administrationHpg miceKidney capsuleGonadotrophin stimulationRenal capsuleHuman ovaryImmunodeficient miceFollicular growthSmall folliclesCryopreservation of immature human oocytes and ovarian tissue: An emerging technology?
Oktay K, Newton H, Aubard Y, Salha O, G.Gosden R. Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology? Fertility And Sterility 1998, 69: 1-7. PMID: 9457923, DOI: 10.1016/s0015-0282(97)00207-0.Peer-Reviewed Original ResearchConceptsOvarian tissueConservation of fertilityHigh-dose chemotherapyOvarian tissue cryopreservationImmature human oocytesOvarian biopsy samplesOvarian tissue bankingNeeds of patientsLong-term survivorshipCryopreservation of oocytesHealthy womenOvarian stromaImmature folliclesTissue cryopreservationPrimordial folliclesBiopsy samplesFollicle growthNeedy patientsImmature oocytesPatientsHuman oocytesDisappointing resultsOocyte fertilityReproductive optionsFollicles
1995
Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1
Oktay K, Schenken R, Nelson J. Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1. Biology Of Reproduction 1995, 53: 295-301. PMID: 7492681, DOI: 10.1095/biolreprod53.2.295.Peer-Reviewed Original ResearchConceptsPCNA expressionPrimary folliclesFollicle growthCell nuclear antigenAntral folliclesFollicular growthPCNA immunoreactivityGranulosa cellsNuclear antigenEarly primary folliclesGranulosa cell layerTransitional folliclesControl ratsAdult ratsPrimordial folliclesSensitive markerPCNA stainingAtretic folliclesRat ovaryOocyte enlargementProliferating Cell Nuclear AntigenEarly signsFolliclesParaffin sectionsPregranulosa cells