2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2012
Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease