Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease