Genetics and molecular pathophysiology of normal pressure hydrocephalus.
Mehta N, Maury E, Buller Z, Duy P, Fortes C, Alper S, Erson-Omay E, Kahle K. Genetics and molecular pathophysiology of normal pressure hydrocephalus. Journal Of Neurosurgery 2024, 1-7. PMID: 39178477, DOI: 10.3171/2024.5.jns24980.Peer-Reviewed Original ResearchIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusPathophysiology of idiopathic normal pressure hydrocephalusIntegrative genetic analysisPressure hydrocephalusPathophysiology of normal pressure hydrocephalusGenomic studiesGenetic analysisGenetic insightsUrinary incontinenceSurgical interventionCerebral ventricleClinical studiesFamilial casesMolecular pathophysiologyCSF dynamicsDisease pathogenesisNeuroinflammatory processesCerebral pressureHydrocephalusGeneticsCognitive impairmentBiomechanical instability of the brain–CSF interface in hydrocephalus
Duy P, Mehta N, Kahle K. Biomechanical instability of the brain–CSF interface in hydrocephalus. Brain 2024, 147: 3274-3285. PMID: 38798141, PMCID: PMC11449143, DOI: 10.1093/brain/awae155.Peer-Reviewed Original ResearchBrain-CSF interfaceBrain parenchymaPost-hemorrhagic hydrocephalusLow intracranial pressureAbnormal biomechanical propertiesNormal pressure hydrocephalusPost-infectiousCongenital hydrocephalusImpaired neurodevelopmentCommunicating hydrocephalusCSF homeostasisBiomechanical instabilityHydrocephalusIntracranial pressureAnimal studiesPressure hydrocephalusArachnoid granulationsPrimary derangementBrain surgeryStudy of hydrocephalusAge groupsCSF reabsorptionVentriculomegalyVentricleSecondary enlargementUtility of cortical tissue analysis in normal pressure hydrocephalus
Greenberg A, Mekbib K, Mehta N, Kiziltug E, Duy P, Smith H, Junkkari A, Leinonen V, Hyman B, Chan D, Curry W, Arnold S, Barker F, Frosch M, Kahle K. Utility of cortical tissue analysis in normal pressure hydrocephalus. Cerebral Cortex 2024, 34: bhae001. PMID: 38275188, PMCID: PMC10839843, DOI: 10.1093/cercor/bhae001.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalus patientsNormal pressure hydrocephalus patientsCerebrospinal fluid shuntsNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusHydrocephalus patientsPressure hydrocephalusOriginal patient cohortCortical pathologyRisks of treatmentPrognostic adjunctClinical improvementTissue analysisNegative pathologyShunt outcomeClinical outcomesPatient cohortUnfavorable outcomePooled analysisSystematic reviewOriginal cohortPooled statisticsLiving patientsConfounding diagnosesPatients