283 Decoding Mechanotransduction in Spinal Pseudoarthrosis: A Mouse Model of Spinal Fusion for Developing Mechanosensitive Osteobiologics
Connolly I, Burns R, Kiapour A, Phan D, Esposito E, Kahle K, Shin J, Hadzipasic M, Shankar G. 283 Decoding Mechanotransduction in Spinal Pseudoarthrosis: A Mouse Model of Spinal Fusion for Developing Mechanosensitive Osteobiologics. Neurosurgery 2024, 70: 80-80. DOI: 10.1227/neu.0000000000002809_283.Peer-Reviewed Original ResearchFusion surgerySpinal fusionFusion bedWeek 4Mouse spinePiezo-1Bone formationSpinal fusion surgeryEvidence of bone fusionIliac crest allograftPA tissuesLoss of osteocytesMouse micro-CT imagesMechanosensitive calcium channelsCalcium channelsSpinal pseudoarthrosisCT scanMouse modelPiezo1-dependent mannerBone fusionPseudoarthrosisNormal spineHistological characterizationCT imagesPromote arthrodesis