Featured Publications
Modelling schizophrenia using human induced pluripotent stem cells
Brennand K, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage F. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011, 473: 221-225. PMID: 21490598, PMCID: PMC3392969, DOI: 10.1038/nature09915.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntipsychotic AgentsCell DifferentiationCells, CulturedCellular ReprogrammingChildDisks Large Homolog 4 ProteinFemaleFibroblastsGene Expression ProfilingGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsLoxapineMaleMembrane ProteinsModels, BiologicalNeuritesNeuronsPhenotypePluripotent Stem CellsReceptors, GlutamateSchizophreniaYoung Adult
2021
Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective
De Los Angeles A, Fernando M, Hall N, Brennand K, Harrison P, Maher B, Weinberger D, Tunbridge E. Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective. Biological Psychiatry 2021, 90: 362-372. PMID: 34176589, PMCID: PMC8375580, DOI: 10.1016/j.biopsych.2021.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models
Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells 2020, 9: 1406. PMID: 32516938, PMCID: PMC7349756, DOI: 10.3390/cells9061406.Peer-Reviewed Original ResearchConceptsCell type-restricted expressionDisease-associated interactionsGene expression profilingHiPSC-derived motor neuronsHuman-induced pluripotent stem cellsPluripotent stem cellsCell-type specific perturbationsImmortalized cell linesRibosomal proteinsGenomic studiesExpression profilingMolecular mechanismsOff-target RNAMouse tissuesCell typesStem cellsPrimary mouse astrocytesExperimental replicatesCell linesMixed speciesMouse astrocytesExpressionMotor neuronsRiboTagCells
2018
New considerations for hiPSC-based models of neuropsychiatric disorders
Hoffman GE, Schrode N, Flaherty E, Brennand KJ. New considerations for hiPSC-based models of neuropsychiatric disorders. Molecular Psychiatry 2018, 24: 49-66. PMID: 29483625, PMCID: PMC6109625, DOI: 10.1038/s41380-018-0029-1.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationHumansInduced Pluripotent Stem CellsMental DisordersModels, BiologicalNeuronsPhenotypeReproducibility of ResultsConceptsHuman-induced pluripotent stem cellsCell type compositionComplex genetic diseasesPluripotent stem cellsComplex genetic disorderField of geneticsCell biologistsBiological convergenceLevel phenotypesAdvanced geneticsCRISPR technologyHuman diseasesPsychiatric genomicsGenetic diseasesStem cellsNeural cellsCommon variantsGeneticsGenetic disordersBiological considerationsCritical insightsCellsGenomicsRecent advancesBiologists
2017
Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS)
Narla S, Lee Y, Benson C, Sarder P, Brennand K, Stachowiak E, Stachowiak M. Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS). Schizophrenia Research 2017, 185: 17-32. PMID: 28094170, PMCID: PMC5507209, DOI: 10.1016/j.schres.2016.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell DifferentiationCells, CulturedFemaleGene Expression Regulation, DevelopmentalGene Regulatory NetworksGenomeGenomicsHumansInduced Pluripotent Stem CellsMaleMicroRNAsModels, BiologicalMutationReceptor, Fibroblast Growth Factor, Type 1Receptor, Notch1SchizophreniaSignal TransductionTranscriptomeYoung AdultConceptsMRNA networkMajor developmental pathwaysIntegrative nuclear FGFR1MiRNA-mRNA networkHuman gene promotersCommon developmental genomesMiRNA genesMiRNA transcriptomeGene networksUpregulated genesGene promoterNuclear FGFR1Genomic etiologyGene dysregulationDisease ontogenyNuclear formGlobal dysregulationDevelopmental pathwaysGenesNeuron formationDistinct pathwaysConcerted actionPotential therapeutic targetTranscriptomeGenome
2016
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
Topol A, Zhu S, Hartley B, English J, Hauberg M, Tran N, Rittenhouse C, Simone A, Ruderfer D, Johnson J, Readhead B, Hadas Y, Gochman P, Wang Y, Shah H, Cagney G, Rapoport J, Gage F, Dudley J, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand K. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Reports 2016, 15: 1024-1036. PMID: 27117414, PMCID: PMC4856588, DOI: 10.1016/j.celrep.2016.03.090.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsControl neural progenitor cellsMiR-9 targetsProgenitor cellsSubset of patientsMiR-9Levels/activitiesMiR-9 expressionSchizophrenia patientsMicroRNA-9Migration deficitsDisease riskNeural migrationAberrant levelsAberrant migrationPatientsMiRNA-9SchizophreniaMigration-associated genesRNA sequencingSZ riskRiskIndirect targetsSubsetCells
2013
Inducing Cellular Aging: Enabling Neurodegeneration-in-a-Dish
Brennand K. Inducing Cellular Aging: Enabling Neurodegeneration-in-a-Dish. Cell Stem Cell 2013, 13: 635-636. PMID: 24315433, PMCID: PMC3908665, DOI: 10.1016/j.stem.2013.11.017.Commentaries, Editorials and LettersMeSH KeywordsAgingAnimalsHumansInduced Pluripotent Stem CellsLamin Type AModels, BiologicalNuclear ProteinsProtein Precursors
2011
Modeling psychiatric disorders through reprogramming
Brennand K, Gage F. Modeling psychiatric disorders through reprogramming. Disease Models & Mechanisms 2011, 5: 26-32. PMID: 21954066, PMCID: PMC3255540, DOI: 10.1242/dmm.008268.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCellular ReprogrammingFibroblastsHumansInduced Pluripotent Stem CellsMental DisordersModels, BiologicalNeuronsInduced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises
Marchetto M, Brennand K, Boyer L, Gage F. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Human Molecular Genetics 2011, 20: r109-r115. PMID: 21828073, PMCID: PMC4447776, DOI: 10.1093/hmg/ddr336.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsHumansInduced Pluripotent Stem CellsModels, BiologicalNervous System DiseasesNeurons
2007
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell DifferentiationCell ProliferationFemaleGenes, ReporterGenetic MarkersGreen Fluorescent ProteinsHistonesIn Vitro TechniquesInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalMosaicismRecombinant Fusion ProteinsTetracyclineConceptsBeta-cell populationBeta cellsBeta-cell replicationHealthy adult miceBeta-cell poolCell populationsDifferentiated beta cellsStem cellsReplacement therapyCell replacement therapyAdult miceIslet growthΒ-cellsProtein expressionCell poolReplicative capacityCell replicationHepatocyte populationAdult stem cellsClonal analysisCellsLevel of fluorescenceFluorescent protein expressionPopulationDiabetes