Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs
Halpern M, Brennand KJ, Gregory J. Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs. Neurobiology Of Disease 2019, 132: 104562. PMID: 31381978, PMCID: PMC6834907, DOI: 10.1016/j.nbd.2019.104562.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAstrocytesCoculture TechniquesHumansInduced Pluripotent Stem CellsNeurodegenerative DiseasesConceptsAmyotrophic lateral sclerosisAstrocyte dysfunctionNeurodegenerative diseasesRole of astrocytesNon-cell autonomous mechanismsFatal neurodegenerative diseaseRisk-associated genesAstrocytic dysfunctionNeural cell typesAstrocyte functionDisease onsetDisease progressionMotor neuronsLateral sclerosisTherapeutic interventionsDysfunctionDisease initiationGenetic factorsPotential targetProgressionAutonomous mechanismsDiseaseStem cellsNeurodegenerationCell typesSpatial genome exploration in the context of cognitive and neurological disease
Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion In Neurobiology 2019, 59: 112-119. PMID: 31255842, PMCID: PMC6889018, DOI: 10.1016/j.conb.2019.05.007.Peer-Reviewed Original ResearchConceptsGenome explorationSpecific gene expression programsImportant regulatory layerTopological chromatin domainsGene expression programsChromosomal contact mapsChromatin domainsGenome organizationExpression programsRegulatory layerTranscriptional regulationChromosomal contactsWidespread remodelingTranscriptomic analysisRepeat sequencesUnexpected linkNeuronal lineageNeural differentiationNon-contiguous sequencesContact mapsAbnormal expansionNeurodegenerative diseasesNew insightsSequenceMouse brain