THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders
Guennewig B, Bitar M, Obiorah I, Hanks J, O’Brien E, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G. THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Translational Psychiatry 2018, 8: 89. PMID: 29691375, PMCID: PMC5915454, DOI: 10.1038/s41398-018-0137-3.Peer-Reviewed Original ResearchConceptsHuman-induced pluripotent stem cellsPluripotent stem cellsHuman iPSC neuronsTranscriptional responseTranscriptomic analysisRNA transcriptomic analysisHuman neural cellsIPSC-neuronsMolecular pathwaysNeuropsychiatric disordersStem cellsNeural cellsDiagnosis-specific differencesGenesTHC exposureNeuronal depolarizationTHC administrationChronic exposureCannabis useNeuronsΔ9-tetrahydrocannabinolStrong associationSignificant alterationsCellsDynamic changes