2010
High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes
Ruiz S, Brennand K, Panopoulos A, Herrerías A, Gage F, Izpisua-Belmonte J. High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLOS ONE 2010, 5: e15526. PMID: 21170306, PMCID: PMC3000364, DOI: 10.1371/journal.pone.0015526.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsHuman somatic cell typesEmbryoid body generationHuman embryonic stem cellsEmbryonic germ layersEmbryonic stem cellsStem cellsInduced pluripotent stem cellsTeratoma formationRegenerative medicineSomatic cell typesPluripotent markersReprogramming efficiencyHuman somatic cellsHiPS cellsHigh-efficient generationGerm layersAutologous cellsEfficiencySomatic cellsSimilar efficiencyPluripotencyNeural cell typesCell typesLayer
2008
Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells
Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells. Current Biology 2008, 18: 890-894. PMID: 18501604, PMCID: PMC2819222, DOI: 10.1016/j.cub.2008.05.010.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsPluripotent stem cellsCell typesIPS cellsStem cellsC-MycTranscription factors Oct4Rare cell typesInduced pluripotent stem cellsCertain cell typesAdult stem cellsInducible lentivirusVitro reprogrammingFactors OCT4Pluripotent cellsEctopic expressionGenetic proofPancreatic β-cellsGerm layersDifferentiated cellsChimeric animalsPluripotency markersDifferentiation stageBeta cellsPancreatic beta cells