2021
Chapter 30 Functional genomics of psychiatric disease risk using genome engineering
Garcia M, Powell S, LaMarca E, Fernando M, Cohen S, Fang G, Akbarian S, Brennand K. Chapter 30 Functional genomics of psychiatric disease risk using genome engineering. 2021, 711-734. DOI: 10.1016/b978-0-12-823577-5.00021-0.ChaptersRisk variantsDisease-relevant cell typesPsychiatric disease riskPluripotent stem cellsFunctional genomicsGenetic risk architectureGenome engineeringComplex geneticsCRISPR engineeringHiPSC modelsCell typesFunctional explorationStem cellsFunctional impactRisk architecturePossible new avenuesGenetic findingsGenetic screeningNew insightsNovel therapeutic approachesFundamental roleNew avenuesDisease pathophysiologyEpigenomeVariants
2016
Spatial genome organization and cognition
Rajarajan P, Gil S, Brennand K, Akbarian S. Spatial genome organization and cognition. Nature Reviews Neuroscience 2016, 17: 681-691. PMID: 27708356, PMCID: PMC5503467, DOI: 10.1038/nrn.2016.124.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPromoter-enhancer interactionsRegulatory sequencesGene transcription start siteSpatial genome organizationNon-coding DNACis-regulatory sequencesHundreds of kilobasesTranscription start siteCRISPR-Cas systemsChromosomal loopingGenome organizationTranscriptional activatorChromosomal conformationCohesin complexGenetic risk architectureTranscriptional regulationStart siteCandidate genesGene expressionStructural variantsDecoy modelsNeurodevelopmental diseasesCrucial layerEditing techniquesProgenitor cells