Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies
Liao C, Moyses-Oliveira M, De Esch C, Bhavsar R, Nuttle X, Li A, Yu A, Burt N, Erdin S, Fu J, Wang M, Morley T, Han L, Consortium C, Dion P, Rouleau G, Zhang B, Brennand K, Talkowski M, Ruderfer D. Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies. Cell Genomics 2023, 3: 100277. PMID: 37082147, PMCID: PMC10112287, DOI: 10.1016/j.xgen.2023.100277.Peer-Reviewed Original ResearchRisk genesNovel risk genesProtein-altering variantsLarge-scale genetic studiesASD risk genesHeritable neurodevelopmental disorderAutism-associated genesCRISPR perturbationsConvergent genesNovel genesTranscriptional consequencesFunctional mutationsGenetic studiesCoexpression patternsDifferential expressionGenesHuman neuronsASD-associationHuman postmortem brainRare variationCoexpressionASD brainNeurodevelopmental disordersPostmortem brainsMutations