2022
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies
Leveille E, Chan LN, Mirza AS, Kume K, Müschen M. SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies. Cellular Signalling 2022, 94: 110331. PMID: 35398488, DOI: 10.1016/j.cellsig.2022.110331.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaB-cell malignanciesT cell receptorB cell receptorB-cell chronic lymphocytic leukemiaPathological B-cellsPoor clinical outcomeAcute lymphoblastic leukemiaExpression of SykT lymphocyte developmentClinical outcomesAggressive diseaseActivation of NFATAutoimmune diseasesLymphoblastic leukemiaT lymphocytesLymphocytic leukemiaCell lymphomaLymphoid malignanciesB cellsPI3K-pathwayOncogenic driversMalignancyNegative selectionPremalignant cells
2019
Recurrence risk evaluation in T1N1M0/T2N0M0/T3N0M0 gastric cancer with TP53 codon 72 polymorphisms
Ohmori Y, Nomura T, Fukushima N, Takahashi F, Iwaya T, Koeda K, Nishizuka S, Consortium M. Recurrence risk evaluation in T1N1M0/T2N0M0/T3N0M0 gastric cancer with TP53 codon 72 polymorphisms. Journal Of Surgical Oncology 2019, 120: 1154-1161. PMID: 31578743, DOI: 10.1002/jso.25718.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCodonFemaleFollow-Up StudiesGastrectomyGenetic Predisposition to DiseaseGenotypeHumansIncidenceJapanMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPolymorphism, Single NucleotideRisk AssessmentStomach NeoplasmsSurvival RateTumor Suppressor Protein p53ConceptsRelapse-free survivalTP53 codon 72 polymorphismArg/ArgCodon 72 polymorphismGastric cancerOverall survivalHazard ratioHigh-risk patient groupsPostoperative adjuvant chemotherapyRecurrence risk evaluationArg/ProPro/Pro groupAdjuvant chemotherapyT3N0M0 patientsCurative intentStudy cohortPatient groupPro polymorphismEntire observation periodPolymorphism statusPRO groupPatientsArg/CancerPro/
2016
Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel
Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS. Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel. PLOS ONE 2016, 11: e0146275. PMID: 26727500, PMCID: PMC4699643, DOI: 10.1371/journal.pone.0146275.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAllelesCell Line, TumorColorectal NeoplasmsDNA Mutational AnalysisDNA PrimersDNA, NeoplasmFemaleGenes, NeoplasmHumansLeukocytes, MononuclearMaleMiddle AgedMultiplex Polymerase Chain ReactionPoint MutationPolymorphism, Single NucleotideSequence Analysis, DNATumor BurdenConceptsPeripheral blood mononuclear cellsTumor burdenColorectal tumorsVariant allele frequencyCurative resectionDroplet digital PCRPlasma DNACancer-associated genesTumor DNATumor burden monitoringUtility of ctDNABlood mononuclear cellsSingle nucleotide variantsGene sequencing panelAllele frequenciesMutation spectrumCancer patientsMononuclear cellsPrimary tumorCtDNA markersClinical utilityHealthy individualsSequencing panelGene point mutationsTumors
2015
A Distinct Subpopulation of Bone Marrow Mesenchymal Stem Cells, Muse Cells, Directly Commit to the Replacement of Liver Components
Katagiri H, Kushida Y, Nojima M, Kuroda Y, Wakao S, Ishida K, Endo F, Kume K, Takahara T, Nitta H, Tsuda H, Dezawa M, Nishizuka SS. A Distinct Subpopulation of Bone Marrow Mesenchymal Stem Cells, Muse Cells, Directly Commit to the Replacement of Liver Components. American Journal Of Transplantation 2015, 16: 468-483. PMID: 26663569, DOI: 10.1111/ajt.13537.Peer-Reviewed Original ResearchConceptsLiver componentsBone marrow mesenchymal stem cellsMarrow mesenchymal stem cellsLiver regenerationBM-MSCsMuse cellsMesenchymal stem cellsLiving-donor liver transplantationSinusoidal endothelial cellsMultilineage-differentiating stress-enduring (Muse) cellsPartial hepatectomy modelStem cellsGraft liverLiver transplantationPolymerase chain reactionCell involvementImmunodeficient miceKupffer cellsSinusoidal cellsPeriportal areasExtrahepatic originHepatectomy modelSpecific subpopulationsEndothelial cellsProgenitor markers
2013
Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer
Matsuo T, Nishizuka SS, Ishida K, Endo F, Katagiri H, Kume K, Ikeda M, Koeda K, Wakabayashi G. Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer. World Journal Of Surgical Oncology 2013, 11: 11. PMID: 23339659, PMCID: PMC3562164, DOI: 10.1186/1477-7819-11-11.Peer-Reviewed Original ResearchConceptsDose-response curveChemosensitivity testGastric cancerResistant cancer cell populationsStandard chemotherapy regimensPeak plasma concentrationDose-response patternDrug dose-response curvesPrimary chemotherapyChemotherapy regimensRecurrent diseaseStandard chemotherapyResultsA totalChemosensitivity evaluationPlasma concentrationsChemosensitivity patternsChemoresistant tumorsResistant patternChemotherapyDrug resistanceDrug sensitivityCancer cell populationsConclusionsThese resultsCisplatinCell populations
2012
Molecular Marker Identification for Relapse Prediction in 5-FU-Based Adjuvant Chemotherapy in Gastric and Colorectal Cancers
Ishida K, Nishizuka SS, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N, Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G. Molecular Marker Identification for Relapse Prediction in 5-FU-Based Adjuvant Chemotherapy in Gastric and Colorectal Cancers. PLOS ONE 2012, 7: e43236. PMID: 22905237, PMCID: PMC3419205, DOI: 10.1371/journal.pone.0043236.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntimetabolites, AntineoplasticBiomarkers, TumorCell Line, TumorChemotherapy, AdjuvantCluster AnalysisColorectal NeoplasmsFluorouracilGene Expression Regulation, NeoplasticHumansImmunohistochemistryMAP Kinase Kinase 4Middle AgedPrognosisRecurrenceRNA, Small InterferingStomach NeoplasmsConceptsAdjuvant chemotherapyNF-κBCancer patientsTissue microarrayProtein expressionColorectal cancer patientsOverall survival rateGastrointestinal tract cancerGastric cancer patientsGastric cancer cell linesCell linesCancer cell linesJNK protein expressionR0 resectionTract cancerColorectal cancerImmunohistochemical examinationClinical significanceSurvival rateRelapse predictionBaseline expressionChemotherapyChemosensitivity markerPatientsGastric