α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15
Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. Scientific Reports 2016, 6: 25895. PMID: 27181033, PMCID: PMC4867652, DOI: 10.1038/srep25895.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-AmanitinAnimalsCell Line, TumorCisplatinDown-RegulationDrug ResistanceEnzyme InhibitorsGene Expression Regulation, NeoplasticHCT116 CellsHeLa CellsHT29 CellsHumansMCF-7 CellsMicePeritoneal NeoplasmsProteomicsSecondary PreventionTATA-Binding Protein Associated FactorsTranscription, GeneticXenograft Model Antitumor AssaysConceptsΑ-amanitinRNA polymerase II inhibitorProtein expression patternsTranscriptional machineryRNA processingProteomic characterizationFunctional screeningTranscriptional levelExpression patternsTAF15II inhibitorsCancer cellsSubstantial frequencyDTC formationCancer relapseCell subpopulationsSubpopulationsTranscriptionMouse modelMachineryRNAPresence of drugsStemnessColoniesExpression