2011
Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons
Fragoso C, Gill TM, McAvay G, Van Ness PH, Yaggi HK, Concato J. Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons. Respiratory Care 2011, 56: 1771-1777. PMID: 21605489, PMCID: PMC3676885, DOI: 10.4187/respcare.01192.Peer-Reviewed Original ResearchConceptsRespiratory symptomsRespiratory impairmentMiddle-aged personsZ-scoreAirflow limitationSpirometric valuesParticipants ages 45Normal age-related changesNutrition Examination SurveyThird National HealthLambda-muMiddle-age personsAge-related changesPulmonary functionExamination SurveyAtherosclerosis RiskNational HealthAge 45Spirometric dataSymptomsMortalityCommunity studyImpairmentScoresValid strategy
2009
The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease
Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM. The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 2009, 181: 446-451. PMID: 20019341, PMCID: PMC3159085, DOI: 10.1164/rccm.200909-1366oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseFEV1/FVCObstructive pulmonary diseaseRisk of deathRespiratory symptomsPulmonary diseaseAdjusted hazard ratioRatio of FEV1Hazard ratioOdds ratioFVCClinical validityFifth percentileZ-scoreIdentifies personsSymptomsWhite personsDiseaseMeaningful outcomesDeathLambda-muPrevalenceRiskRepresentative sampleHigh threshold