A Randomized Trial of Nebulized Epinephrine vs Albuterol in the Emergency Department Treatment of Bronchiolitis
Mull CC, Scarfone RJ, Ferri LR, Carlin T, Salvaggio C, Bechtel KA, Trephan MA, Rissman RL, Gracely EJ. A Randomized Trial of Nebulized Epinephrine vs Albuterol in the Emergency Department Treatment of Bronchiolitis. JAMA Pediatrics 2004, 158: 113-118. PMID: 14757602, DOI: 10.1001/archpedi.158.2.113.Peer-Reviewed Original ResearchConceptsEpinephrine-treated groupEmergency department treatmentED dischargeClinical scoresNebulized epinephrineIll infantsOutcome measuresAntecedent upper respiratory tract infectionRespiratory rateRoom air oxygen saturationUpper respiratory tract infectionNew-onset wheezingRoom air saturationDouble-blind fashionProportion of patientsRespiratory tract infectionsMean clinical scoreSecondary outcome measuresPrimary outcome measureMonths of ageNebulized albuterolTract infectionsRelapse rateMedian timeRacemic epinephrine