Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials
Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise ME, McDonald LC, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine 2015, 33: 6241-6249. PMID: 26450660, PMCID: PMC4702247, DOI: 10.1016/j.vaccine.2015.09.078.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramHigh-risk groupRisk groupsRisk scoreIndex hospitalizationHospital dischargeDerivation cohortVaccine trialsValidation cohortDifficile infectionCox proportional hazards modelRisk of CDIAcute care hospitalizationIdentification of patientsClostridium difficile infectionHospital discharge dataNumber of hospitalizationsLow-risk groupProportional hazards modelLarge academic centerAdmission diagnosisPrimary outcomeInpatient stayPatient populationPharmacy dataRisk Factors for Invasive Methicillin-Resistant Staphylococcus aureus Infection After Recent Discharge From an Acute-Care Hospitalization, 2011–2013
Epstein L, Mu Y, Belflower R, Scott J, Ray S, Dumyati G, Felsen C, Petit S, Yousey-Hindes K, Nadle J, Pasutti L, Lynfield R, Warnke L, Schaffner W, Leib K, Kallen AJ, Fridkin SK, Lessa FC. Risk Factors for Invasive Methicillin-Resistant Staphylococcus aureus Infection After Recent Discharge From an Acute-Care Hospitalization, 2011–2013. Clinical Infectious Diseases 2015, 62: 45-52. PMID: 26338787, PMCID: PMC6557163, DOI: 10.1093/cid/civ777.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureus (MRSA) infectionsInvasive MRSA infectionsStaphylococcus aureus infectionCase patientsMRSA infectionRisk factorsMRSA colonizationHospital dischargeAureus infectionInvasive methicillin-resistant Staphylococcus aureus (MRSA) infectionsNursing homesInvasive devicesChronic woundsPrevention effortsAcute care hospitalizationIndependent risk factorMonths of dischargeCentral venous cathetersMedical record reviewSterile body sitesCase-control studyConditional logistic regressionEligible case patientsInvasive MRSAPostdischarge period