2024
Formative evaluation of an emergency department clinical decision support system for agitation symptoms: a study protocol
Wong A, Nath B, Shah D, Kumar A, Brinker M, Faustino I, Boyce M, Dziura J, Heckmann R, Yonkers K, Bernstein S, Adapa K, Taylor R, Ovchinnikova P, McCall T, Melnick E. Formative evaluation of an emergency department clinical decision support system for agitation symptoms: a study protocol. BMJ Open 2024, 14: e082834. PMID: 38373857, PMCID: PMC10882402, DOI: 10.1136/bmjopen-2023-082834.Peer-Reviewed Original ResearchConceptsComputerised clinical decision supportED treatRestraint useExperiences of restraint useMental health-related visitsEmergency departmentPrevent agitationSystems-related factorsImprove patient experienceClinical decision support systemsRegional health systemClinical decision supportDe-escalation techniquesRandomised controlled trialsFormative evaluationPeer-reviewed journalsBest-practice guidanceAt-risk populationsCDS toolsThematic saturationED cliniciansPatient experienceED sitesHealth systemED physicians
2022
Psychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review
Handy AB, Greenfield SF, Yonkers KA, Payne LA. Psychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review. Harvard Review Of Psychiatry 2022, 30: 100-117. PMID: 35267252, PMCID: PMC8906247, DOI: 10.1097/hrp.0000000000000329.Peer-Reviewed Original ResearchConceptsMental healthMenstrual cycleAnxiety disordersWomen's mental healthPsychiatric symptomsSocial anxiety disorderPosttraumatic stress disorderLuteal phaseObsessive-compulsive disorderMenstrual cycle-dependent fluctuationGeneralized anxiety disorderAdult womenSuicide/suicide attemptsBody of researchStress disorderBorderline personality disorderMenstrual cycle phaseBehavioral interventionsAlcohol useCyclic exacerbationsPanic disorderSymptom exacerbationSubjective effectsMenstrual phasePersonality disorder
2021
“A good mother”: Impact of motherhood identity on women's substance use and engagement in treatment across the lifespan
Adams ZM, Ginapp CM, Price CR, Qin Y, Madden LM, Yonkers K, Meyer JP. “A good mother”: Impact of motherhood identity on women's substance use and engagement in treatment across the lifespan. Journal Of Substance Use And Addiction Treatment 2021, 130: 108474. PMID: 34118710, PMCID: PMC8478714, DOI: 10.1016/j.jsat.2021.108474.Peer-Reviewed Original ResearchConceptsSUD treatmentSubstance useSubstance use disorder treatmentSUD treatment programsUse disorder treatmentWomen's substance usePostpartum periodMost womenStudy staffIndependent authorsTreatment engagementDisorder treatmentTreatment programWomenSUD recoveryTreatmentMothersSpecific barriersChildrenResidential programsMiddle adulthoodFocus groupsCaretakersQualitative interviewsPregnancy
2020
Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience
Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.Peer-Reviewed Original ResearchAssociation of Pregnancy Contexts with Depression and Low Social Support in Early Pregnancy
Lundsberg LS, Cutler AS, Stanwood NL, Yonkers KA, Gariepy AM. Association of Pregnancy Contexts with Depression and Low Social Support in Early Pregnancy. Perspectives On Sexual And Reproductive Health 2020, 52: 161-170. PMID: 33047499, DOI: 10.1363/psrh.12155.Peer-Reviewed Original ResearchConceptsLow social supportPregnancy contextPerinatal depressionMultivariable logistic regression analysisSocial supportOdds of depressionPotential risk factorsLogistic regression analysisRegression analysisSocial Support IndexAntenatal depressionWeeks' gestationPrevious diagnosisDepression screenEarly pregnancyEDSS scoresPregnancy intentionRisk factorsPregnancy timingUnplanned pregnancyPregnancy testingPregnancyPregnancy measuresAbortion careDepressionCost and cost-effectiveness of three strategies for implementing motivational interviewing for substance misuse on medical inpatient units
Olmstead TA, Yonkers KA, Forray A, Zimbrean P, Gilstad-Hayden K, Martino S. Cost and cost-effectiveness of three strategies for implementing motivational interviewing for substance misuse on medical inpatient units. Drug And Alcohol Dependence 2020, 214: 108156. PMID: 32659637, PMCID: PMC7448551, DOI: 10.1016/j.drugalcdep.2020.108156.Peer-Reviewed Original Research
2019
The Most Valuable Resource Is Time: Insights From a Novel National Program to Improve Retention of Physician-Scientists With Caregiving Responsibilities.
Jones RD, Miller J, Vitous CA, Krenz C, Brady KT, Brown AJ, Daumit GL, Drake AF, Fraser VJ, Hartmann KE, Hochman JS, Girdler S, Libby AM, Mangurian C, Regensteiner JG, Yonkers K, Jagsi R. The Most Valuable Resource Is Time: Insights From a Novel National Program to Improve Retention of Physician-Scientists With Caregiving Responsibilities. Academic Medicine 2019, 94: 1746-1756. PMID: 31348060, DOI: 10.1097/acm.0000000000002903.Peer-Reviewed Original ResearchIdentification of substance use disorders among pregnant women: A comparison of screeners
Chang G, Ondersma SJ, Blake-Lamb T, Gilstad-Hayden K, Orav EJ, Yonkers KA. Identification of substance use disorders among pregnant women: A comparison of screeners. Drug And Alcohol Dependence 2019, 205: 107651. PMID: 31683243, DOI: 10.1016/j.drugalcdep.2019.107651.Peer-Reviewed Original ResearchConceptsSubstance use disordersPregnant womenUse disordersAlcohol use disorderDrug use questionnaireMINI diagnostic interviewRate of useMean ageDiagnostic criteriaQuick screenDiagnostic InterviewIdeal questionnaireCRAFFTDisordersWomenModest abilityReference standardUse QuestionnaireQuestionnaireScreenerComparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta‐analysis
Levis B, McMillan D, Sun Y, He C, Rice DB, Krishnan A, Wu Y, Azar M, Sanchez TA, Chiovitti MJ, Bhandari PM, Neupane D, Saadat N, Riehm KE, Imran M, Boruff JT, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, Patten SB, Shrier I, Ziegelstein RC, Comeau L, Mitchell ND, Tonelli M, Vigod SN, Aceti F, Alvarado R, Alvarado‐Esquivel C, Bakare MO, Barnes J, Beck CT, Bindt C, Boyce PM, Bunevicius A, Castro e Couto T, Chaudron LH, Correa H, de Figueiredo F, Eapen V, Fernandes M, Figueiredo B, Fisher JRW, Garcia‐Esteve L, Giardinelli L, Helle N, Howard LM, Khalifa DS, Kohlhoff J, Kusminskas L, Kozinszky Z, Lelli L, Leonardou AA, Lewis BA, Maes M, Meuti V, Radoš S, García P, Nishi D, E‐Andjafono D, Robertson‐Blackmore E, Rochat TJ, Rowe HJ, Siu BWM, Skalkidou A, Stein A, Stewart RC, Su K, Sundström‐Poromaa I, Tadinac M, Tandon SD, Tendais I, Thiagayson P, Töreki A, Torres‐Giménez A, Tran TD, Trevillion K, Turner K, Vega‐Dienstmaier J, Wynter K, Yonkers KA, Benedetti A, Thombs BD. Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta‐analysis. International Journal Of Methods In Psychiatric Research 2019, 28: e1803. PMID: 31568624, PMCID: PMC7027670, DOI: 10.1002/mpr.1803.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewEdinburgh Postnatal Depression ScaleIndividual participant dataDiagnostic InterviewEPDS scoresPatient Health Questionnaire-9Mini International Neuropsychiatric InterviewParticipant dataDifferent diagnostic interviewsPostnatal Depression ScaleInternational Neuropsychiatric InterviewStructured Clinical InterviewPrevious individual participant dataMINI diagnostic interviewQuestionnaire-9Neuropsychiatric InterviewMajor depressionDepression ScaleDepressive symptomsClinical InterviewParticipant characteristicsLinear mixed modelsPregnancyPostpartumSCIDImplementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial
Martino S, Zimbrean P, Forray A, Kaufman JS, Desan PH, Olmstead TA, Gilstad-Hayden K, Gueorguieva R, Yonkers KA. Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial. Journal Of General Internal Medicine 2019, 34: 2520-2529. PMID: 31468342, PMCID: PMC6848470, DOI: 10.1007/s11606-019-05257-3.Peer-Reviewed Original ResearchConceptsConsultation-liaison serviceSubstance misuseMotivational interviewMedical inpatientsGeneral medical inpatient servicesMedical inpatient servicesGeneral medical inpatientsStudy-eligible patientsMedical inpatient unitsAcute care hospitalsMain MeasuresPrimary outcomesMedical education workshopSecondary outcomesCare hospitalControlled TrialsEffective implementation strategiesMeasuresPrimary outcomesMedical HospitalInpatient unitInpatient servicesMedical ordersPatientsPatients' statementsMotivational interviewingInpatientsAccuracy of five self‐report screening instruments for substance use in pregnancy
Ondersma SJ, Chang G, Blake‐Lamb T, Gilstad‐Hayden K, Orav J, Beatty JR, Goyert GL, Yonkers KA. Accuracy of five self‐report screening instruments for substance use in pregnancy. Addiction 2019, 114: 1683-1693. PMID: 31216102, PMCID: PMC8407406, DOI: 10.1111/add.14651.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBlack or African AmericanCigarette SmokingFemaleHispanic or LatinoHumansMarijuana UseMass ScreeningOpioid-Related DisordersPregnancyPregnancy ComplicationsSelf ReportSensitivity and SpecificitySubstance Abuse DetectionSubstance-Related DisordersUnited StatesWhite PeopleYoung AdultAssessment of an electronic and clinician-delivered brief intervention on cigarette, alcohol and illicit drug use among women in a reproductive healthcare clinic
Forray A, Martino S, Gilstad-Hayden K, Kershaw T, Ondersma S, Olmstead T, Yonkers KA. Assessment of an electronic and clinician-delivered brief intervention on cigarette, alcohol and illicit drug use among women in a reproductive healthcare clinic. Addictive Behaviors 2019, 96: 156-163. PMID: 31100713, PMCID: PMC6579708, DOI: 10.1016/j.addbeh.2019.05.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcohol-Related DisordersAmbulatory Care FacilitiesCigarette SmokingDiagnosis, Computer-AssistedFemaleHealth PersonnelHumansMass ScreeningMiddle AgedMotivational InterviewingReferral and ConsultationReproductive Health ServicesSmoking ReductionSubstance-Related DisordersTherapy, Computer-AssistedTreatment OutcomeYoung AdultConceptsEnhanced usual careIllicit drug useE-SBIRTDrug useCigarette useBrief interventionIllicit drugsAlcohol useSubstance useReproductive-age womenReproductive health clinicsGreater reductionSubstance use disordersReproductive healthcare clinicsUse of cigarettesPrimary substancePrimary substance useClinician-delivered interventionSBIRT interventionOverall substance useUsual careMonth 3Present studyReproductive yearsHealth clinics
2017
A randomized controlled trial of screening and brief interventions for substance misuse in reproductive health
Martino S, Ondersma SJ, Forray A, Olmstead TA, Gilstad-Hayden K, Howell HB, Kershaw T, Yonkers KA. A randomized controlled trial of screening and brief interventions for substance misuse in reproductive health. American Journal Of Obstetrics And Gynecology 2017, 218: 322.e1-322.e12. PMID: 29247636, PMCID: PMC6896206, DOI: 10.1016/j.ajog.2017.12.005.Peer-Reviewed Original ResearchConceptsEnhanced usual care groupPrimary substance useUsual care groupUsual careBrief interventionTreatment useSubstance useCare groupSubstance misuseReproductive health settingsEnhanced usual careTrial of screeningDays/monthMonths of useGeneralized estimation equationsCoprimary outcomesPrescription medicationsReproductive centerHealthcare centersPregnancy statusHealth settingsReferralReproductive healthMean daysCareAssociation of Panic Disorder, Generalized Anxiety Disorder, and Benzodiazepine Treatment During Pregnancy With Risk of Adverse Birth Outcomes
Yonkers KA, Gilstad-Hayden K, Forray A, Lipkind HS. Association of Panic Disorder, Generalized Anxiety Disorder, and Benzodiazepine Treatment During Pregnancy With Risk of Adverse Birth Outcomes. JAMA Psychiatry 2017, 74: 1145-1152. PMID: 28903165, PMCID: PMC5710298, DOI: 10.1001/jamapsychiatry.2017.2733.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitor useAdverse birth outcomesLow birth weightSerotonin reuptake inhibitorsWeeks of pregnancyHypertensive diseaseDuration of gestationRespiratory interventionsVentilatory supportCesarean deliveryReuptake inhibitorsPanic disorderPregnancy outcomesInhibitor usePreterm birthBirth outcomesBenzodiazepine treatmentBirth weightAnxiety disordersWorld Mental Health Composite International Diagnostic InterviewPrevious adverse birth outcomesComposite International Diagnostic InterviewAdverse pregnancy complicationsMaternal panic disorderNeonatal pregnancy outcomesPostpartum Contraceptive use and Rapid Repeat Pregnancy Among Women who use Substances
Loree AM, Gariepy A, Ruger JP, Yonkers KA. Postpartum Contraceptive use and Rapid Repeat Pregnancy Among Women who use Substances. Substance Use & Misuse 2017, 53: 162-169. PMID: 28937912, PMCID: PMC6025459, DOI: 10.1080/10826084.2017.1327976.Peer-Reviewed Original ResearchConceptsRapid repeat pregnancyPostpartum contraceptive useRepeat pregnancyContraceptive usePostpartum womenRandomized clinical trialsOB/GYN clinicPrenatal substance exposureEffective contraceptive useIllicit drug useContraceptive initiationWeeks' gestationPregnant womenSubstance use historiesPostpartum contraceptionClinical trialsSubstance exposurePregnancyDrug useSecondary analysisIllicit substancesSubstance useWomenUse historyDepoProvera
2016
Are pregnancy planning and pregnancy timing associated with maternal psychiatric illness, psychological distress and support during pregnancy?
Gariepy AM, Lundsberg LS, Miller D, Stanwood NL, Yonkers KA. Are pregnancy planning and pregnancy timing associated with maternal psychiatric illness, psychological distress and support during pregnancy? Journal Of Affective Disorders 2016, 205: 87-94. PMID: 27423065, PMCID: PMC5048515, DOI: 10.1016/j.jad.2016.06.058.Peer-Reviewed Original ResearchConceptsMajor depressive episodeCohen's Perceived Stress ScaleMaternal psychiatric illnessPregnancy planningPsychiatric illnessHighest quartilePsychological distressPregnancy timingComposite International Diagnostic InterviewMultivariable logistic regressionImpact of depressionGeneral anxiety disorderLow social supportSocial Support InventoryProspective cohortPreterm birthPregnant womenDepressive episodeUnplanned pregnancyPerceived Stress ScalePregnancyPsychiatric diagnosisPsychiatric conditionsSecondary analysisDiagnostic InterviewEarly Childhood Adversity and Pregnancy Outcomes
Smith MV, Gotman N, Yonkers KA. Early Childhood Adversity and Pregnancy Outcomes. Maternal And Child Health Journal 2016, 20: 790-798. PMID: 26762511, PMCID: PMC4849279, DOI: 10.1007/s10995-015-1909-5.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesGestational agePregnancy outcomesBirth weightConclusions ACEsComposite International Diagnostic InterviewEarly Trauma Inventory Self Report-Short FormMaternal reproductive healthShorter gestational ageAdditional adverse childhood experienceDelivery of offspringPregnant womenHealth habitsPsychiatric illnessPsychiatric diagnosisReproductive healthDiagnostic InterviewChildhood adversityShort formMultiple mediatorsAgeChildhood experiencesMediatorsMethods ExposureOutcomes
2015
Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial
Yonkers KA, Kornstein SG, Gueorguieva R, Merry B, Van Steenburgh K, Altemus M. Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2015, 72: 1037-1044. PMID: 26351969, PMCID: PMC4811029, DOI: 10.1001/jamapsychiatry.2015.1472.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderSymptom-onset dosingSerotonin reuptake inhibitorsDays of mensesSSRI withdrawalSymptom onsetSymptomatic daysMenstrual cycleClinical trialsDysphoric disorderOutcome measuresScale scoreSRI treatmentTreatment of PMDDClinical Global Impression ScaleAbrupt treatment cessationDepressive Symptomatology-ClinicianTotal DRSP scoresSecondary outcome measuresPrimary outcome measureGlobal Impression ScaleIDS-C scoresUniversity Medical CenterSertraline hydrochlorideBeginning of mensesAre pregnancy planning and timing associated with preterm or small for gestational age births?
Gariepy AM, Lundsberg LS, Stolar M, Stanwood NL, Yonkers KA. Are pregnancy planning and timing associated with preterm or small for gestational age births? Fertility And Sterility 2015, 104: 1484-1492. PMID: 26364840, PMCID: PMC4663160, DOI: 10.1016/j.fertnstert.2015.08.012.Peer-Reviewed Original ResearchConceptsGestational-age birthsPregnancy planningAge birthGestational ageSignificant associationGestational age infantsProspective cohort studyMedical record abstractionHigh-risk populationMultiple confounding factorsMaternal demographicsCohort studyPreterm birthSingleton pregnanciesRecord abstractionPregnant womenAge infantsRisk factorsPregnancy timingHigh prevalenceLarge cohortPretermMAIN OUTCOMEMedical conditionsOutcome dataObstetric and Neonatal Outcomes After Antipsychotic Medication Exposure in Pregnancy
Coughlin CG, Blackwell KA, Bartley C, Hay M, Yonkers KA, Bloch MH. Obstetric and Neonatal Outcomes After Antipsychotic Medication Exposure in Pregnancy. Obstetrics And Gynecology 2015, 125: 1224-1235. PMID: 25932852, PMCID: PMC4418034, DOI: 10.1097/aog.0000000000000759.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesGestational-age birthsAntipsychotic exposureNeonatal outcomesCohort studyBirth outcomesAntipsychotic medicationMajor malformationsBirth weightOdds ratioAntipsychotic medication exposureNeonatal birth weightPooled odds ratioPotential risk factorsUnexposed pregnanciesMedication exposurePreterm deliveryGestational ageAntipsychotic treatmentElective terminationPossible confoundersReproductive ageRisk factorsSpontaneous abortionSTUDY SELECTION