2006
IL-10 regulation of lupus in the NZM2410 murine model
Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L. IL-10 regulation of lupus in the NZM2410 murine model. Laboratory Investigation 2006, 86: 1136-1148. PMID: 16924244, DOI: 10.1038/labinvest.3700468.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-Lymphocyte SubsetsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleGene Expression RegulationGene Transfer TechniquesGenetic Predisposition to DiseaseGenetic TherapyInterleukin-10KidneyLupus Erythematosus, SystemicLupus NephritisMiceMice, CongenicMice, Inbred C57BLMice, Inbred NZBReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpecific Pathogen-Free OrganismsSpleenConceptsIL-10T cell activationMurine modelB cellsElevated IL-10IL-10 levelsSubset of CD4Auto-antibody productionB-cell phenotypeMajor effector armMonths of ageIL-10 regulationMuscle gene deliveryClinical nephritisSLE patientsRegulatory cellsProinflammatory responseSystemic autoimmunityRegulatory cytokinesEffector armSLE susceptibility lociT cellsC57BL/6 backgroundMyeloid cellsCongenic model
2004
Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse
Blenman KR, Bahjat FR, Moldawer LL, Morel L. Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clinical Immunology 2004, 110: 124-133. PMID: 15003809, DOI: 10.1016/j.clim.2003.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDApoptosisAspartate AminotransferasesCaspase 3CaspasesCytotoxicity Tests, ImmunologicFemaleGalactosamineIn Situ Nick-End LabelingInterleukin-10Interleukin-6LipopolysaccharidesLiverLupus Erythematosus, SystemicMaleMiceMice, CongenicMice, Inbred C57BLReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alpha