2019
Pathology of B cell and neutrophil infiltration in the YUMMER1.7 mouse model of spontaneous melanoma tumor regression
Blenman K, Wang J, Cowper S, Bosenberg M. Pathology of B cell and neutrophil infiltration in the YUMMER1.7 mouse model of spontaneous melanoma tumor regression. The Journal Of Immunology 2019, 202: 136.25-136.25. DOI: 10.4049/jimmunol.202.supp.136.25.Peer-Reviewed Original ResearchB cellsMelanoma cellsTumor regressionPlasmablasts/plasma cellsTumor-infiltrating B cellsLonger progression-free survivalMelanoma tumor regressionProgression-free survivalAdaptive immune responsesB cell numbersNeutrophil extracellular trapsNeutrophil infiltrationImmunotherapy treatmentSpontaneous regressionMetastatic melanomaAdverse reactionsGeographic necrosisImmune cellsNeutrophil responseHistological changesExtracellular trapsPlasma cellsImmune responseTherapy showTumor massPathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma
Blenman KRM, Wang J, Cowper S, Bosenberg M. Pathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma. Pigment Cell & Melanoma Research 2019, 32: 448-457. PMID: 30702217, PMCID: PMC6500596, DOI: 10.1111/pcmr.12769.Peer-Reviewed Original ResearchConceptsTumor regressionB cellsMelanoma cellsNeutrophil extracellular trapsNeutrophil countAdverse reactionsGeographic necrosisNeutrophil responseExtracellular trapsHistological changesPlasma cellsMurine modelHost responseTumor microenvironmentImmunotherapyNeutrophilsTumorsRegression modelsCellsRegressionLike formationImmunocompetentPlasmablastsEpithelioidMelanoma
2018
Sentinel lymph node B cells can predict disease-free survival in breast cancer patients
Blenman KRM, He TF, Frankel PH, Ruel NH, Schwartz EJ, Krag DN, Tan LK, Yim JH, Mortimer JE, Yuan Y, Lee PP. Sentinel lymph node B cells can predict disease-free survival in breast cancer patients. Npj Breast Cancer 2018, 4: 28. PMID: 30155518, PMCID: PMC6107630, DOI: 10.1038/s41523-018-0081-7.Peer-Reviewed Original ResearchSentinel lymph nodesTriple-negative breast cancerBreast cancer patientsB cellsLymph nodesCancer patientsImmune cellsBreast cancerNegative triple negative breast cancerTumor-negative patientsTumor-positive nodesDisease-free survivalAdditional prognostic informationTNM staging systemTumor invasion statusPositive nodesNegative patientsSentinel lymphDendritic cellsStaging systemPrognostic informationUnivariate analysisT cellsDiscovery cohortSeparate cohort
2017
Correlation of sentinel lymph node immune cells with disease-free survival and metastasis in breast cancer patients using 4-color chromogen-based immunohistochemistry and quantitative imaging microscopy
Blenman K. Correlation of sentinel lymph node immune cells with disease-free survival and metastasis in breast cancer patients using 4-color chromogen-based immunohistochemistry and quantitative imaging microscopy. The Journal Of Immunology 2017, 198: 197.7-197.7. DOI: 10.4049/jimmunol.198.supp.197.7.Peer-Reviewed Original ResearchDisease-free survivalShorter disease-free survivalOnly immune cellsBreast cancer patientsT cellsCancer cell invasionImmune cellsB cellsDistant metastasisCancer patientsDendritic cellsLocal metastasisCell invasionOdds of metastasisT cell reductionCancer cellsBreast cancer cohortSentinel lymphUnivariate analysisCancer cohortPatientsMetastasisLogistic regressionCell reductionSurvival
2006
IL-10 regulation of lupus in the NZM2410 murine model
Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L. IL-10 regulation of lupus in the NZM2410 murine model. Laboratory Investigation 2006, 86: 1136-1148. PMID: 16924244, DOI: 10.1038/labinvest.3700468.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-Lymphocyte SubsetsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleGene Expression RegulationGene Transfer TechniquesGenetic Predisposition to DiseaseGenetic TherapyInterleukin-10KidneyLupus Erythematosus, SystemicLupus NephritisMiceMice, CongenicMice, Inbred C57BLMice, Inbred NZBReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpecific Pathogen-Free OrganismsSpleenConceptsIL-10T cell activationMurine modelB cellsElevated IL-10IL-10 levelsSubset of CD4Auto-antibody productionB-cell phenotypeMajor effector armMonths of ageIL-10 regulationMuscle gene deliveryClinical nephritisSLE patientsRegulatory cellsProinflammatory responseSystemic autoimmunityRegulatory cytokinesEffector armSLE susceptibility lociT cellsC57BL/6 backgroundMyeloid cellsCongenic model
2000
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
Morel L, Croker B, Blenman K, Mohan C, Huang G, Gilkeson G, Wakeland E. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6670-6675. PMID: 10841565, PMCID: PMC18697, DOI: 10.1073/pnas.97.12.6670.Peer-Reviewed Original ResearchConceptsLoss of toleranceSystemic autoimmunityLupus-prone NZM2410 mouseFull disease expressionSevere systemic autoimmunitySystemic lupus erythematosusLupus-prone strainsLupus susceptibility genesFatal glomerulonephritisFatal lupusSevere glomerulonephritisLupus erythematosusKidney failureT cellsMurine strainsC57BL/6 backgroundB cellsAutoimmune phenotypeDisease pathogenesisNZM2410 miceTherapeutic interventionsFatal diseaseDisease expressionCongenic dissectionNuclear antigen