2023
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2020
Epigenetics, Development, and Psychopathology
O'Donnell KJ, Meaney MJ. Epigenetics, Development, and Psychopathology. Annual Review Of Clinical Psychology 2020, 16: 1-24. PMID: 32084320, DOI: 10.1146/annurev-clinpsy-050718-095530.Peer-Reviewed Original Research
2019
Biological embedding of experience: A primer on epigenetics
Aristizabal MJ, Anreiter I, Halldorsdottir T, Odgers CL, McDade TW, Goldenberg A, Mostafavi S, Kobor MS, Binder EB, Sokolowski MB, O'Donnell KJ. Biological embedding of experience: A primer on epigenetics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23261-23269. PMID: 31624126, PMCID: PMC7519272, DOI: 10.1073/pnas.1820838116.BooksConceptsEpigenetic mechanismsSpecific epigenetic mechanismsEpigenetic landscapeEpigenome editingDNA sequencesBiological embeddingGene expressionBiological processesCell typesComparative animalHuman longitudinal studiesMolecular profilingPotential roleCorrelative dataEpigenomeGenomeRecent advancesEpigeneticsEditingProfilingCausal dataPrimersMechanismSequenceExpression
2015
Neuroanatomic Differences Associated With Stress Susceptibility and Resilience
Anacker C, Scholz J, O’Donnell K, Allemang-Grand R, Diorio J, Bagot RC, Nestler EJ, Hen R, Lerch JP, Meaney MJ. Neuroanatomic Differences Associated With Stress Susceptibility and Resilience. Biological Psychiatry 2015, 79: 840-849. PMID: 26422005, PMCID: PMC5885767, DOI: 10.1016/j.biopsych.2015.08.009.Peer-Reviewed Original ResearchConceptsVentral tegmental areaMagnetic resonance imagingBrain regionsHippocampal CA3Resilient miceAnatomic differencesResonance imagingNeuroanatomic differencesStructural covarianceStructural magnetic resonance imagingSocial defeat stressLocal brain volumeT2-weighted sequencesDiffusion tensor imagingStress susceptibilitySocial avoidanceC57BL/6 miceControl miceStria terminalsRaphe nucleusPeriaqueductal grayTegmental areaBed nucleusDefeat stressNucleus accumbens
2014
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.Peer-Reviewed Original ResearchConceptsExpression of genesParent-offspring interactionsEpigenetic stateEpigenetic mechanismsEpigenetic programmingEpigenetic studiesStress responseGenesNonhuman speciesAdrenal functionExpressionSpeciesEarly life adversityEarly childhood adversityLater riskFuture studiesChildhood adversityLife adversityFunctionSocial adversityAlters
2009
Prenatal stress and the programming of the HPA axis
Glover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisPrenatal stressLong-term effectsIndependent prospective studiesHPA axis responseBasal cortisol levelsProspective studyAxis responseAnimal studiesCognitive alterationsCortisol responseCortisol levelsCognitive outcomesOutcomesRecent studiesGenetic strainsChildrenLittle evidenceOffspringGestationStudy