2024
Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment
Tchalova K, Lydon J, Atkinson L, Fleming A, Kennedy J, Lecompte V, Meaney M, Moss E, O’Donnell K, O’Donnell K, Silveira P, Sokolowski M, Steiner M, Bartz J. Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational Psychiatry 2024, 14: 181. PMID: 38580654, PMCID: PMC10997775, DOI: 10.1038/s41398-024-02888-x.Peer-Reviewed Original ResearchConceptsMaternal sensitivityChild attachmentAttachment behaviorExpression of attachment behaviorLevels of maternal sensitivityOPRM1 A118G genotypeInfluence of maternal sensitivityNon-human animal researchAmbivalent attachment patternsStrange Situation paradigmMu-opioid receptor geneOPRM1 A118G polymorphismA118G genotypeChildren's attachment stylesMother-child interactionA118G polymorphismEndogenous opioid systemMinor G alleleSensitive maternal careMother-infant attachmentInfant rhesus macaquesG alleleC77G polymorphismReceptor geneSituation paradigm
2022
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
Pagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort. International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.Peer-Reviewed Original ResearchConceptsMaternal mental healthMental healthMean GAD-7 scorePregnant personsGAD-7 scoresNon-pandemic periodMental health assessmentCanada 2Public health policyLevel of depressionDepressive scoresMaternal depressionChinese cohortEDPS scoreCOVID-19 public health policiesCOVID-19 experienceHealth policyCohortSociodemographic variablesSelf-reported dataConception cohortsHealth assessmentCOVID-19COVID-19 pandemicScoresIntegrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypes
2021
Impact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based study
Li M, O'Donnell KJ, Caron J, D'Arcy C, Meng X. Impact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based study. BMJ Open 2021, 11: e038409. PMID: 33593762, PMCID: PMC7888321, DOI: 10.1136/bmjopen-2020-038409.Peer-Reviewed Original ResearchConceptsOffspring's mental health
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylomeAgreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time
Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics 2018, 13: 19-32. PMID: 29381404, PMCID: PMC5837078, DOI: 10.1080/15592294.2017.1411443.Peer-Reviewed Original ResearchBrain-Derived Neurotrophic FactorCanadaCatechol O-MethyltransferaseDNA MethylationDried Blood Spot TestingEpigenesis, GeneticFemaleHumansMaleMouth MucosaNetherlandsOligonucleotide Array Sequence AnalysisReceptors, Dopamine D2Receptors, Dopamine D4Receptors, OxytocinReproducibility of ResultsSerotonin Plasma Membrane Transport ProteinsTime Factors