Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity
Iturria-Medina Y, Adewale Q, Khan A, Ducharme S, Rosa-Neto P, O'Donnell K, Petyuk V, Gauthier S, De Jager P, Breitner J, Bennett D. Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity. Science Advances 2022, 8: eabo6764. PMID: 36399579, PMCID: PMC9674284, DOI: 10.1126/sciadv.abo6764.Peer-Reviewed Original ResearchConceptsMolecular taxonomy of ADAlzheimer's diseaseMolecular dataAlzheimer's disease progressionGenetic variationDNA methylationPattern of alterationsAD dementia progressionAD variantsCell typesPostmortem brainsHeterogeneous disorderBiological domainSpatial pattern of alterationAlzheimerClinical heterogeneityTaxonomyAD subtypesMetabolomic profilesSpatial patternsMolecular indicesAdvanced machine learning analysisDisease progressionRNADNA