2022
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbility
2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding