Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypes