2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal life
2012
Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age
Auyeung B, Ahluwalia J, Thomson L, Taylor K, Hackett G, O’Donnell K, Baron-Cohen S. Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age. Molecular Autism 2012, 3: 17. PMID: 23231861, PMCID: PMC3554559, DOI: 10.1186/2040-2392-3-17.Peer-Reviewed Original ResearchMonths of ageAndrogen exposureSex steroid hormone effectsFT levelsSex steroid hormone levelsSex steroid hormonesSteroid hormone levelsSecond trimester amniocentesisSteroid hormone effectsMonths old toddlersPostnatal androgen exposurePrenatal androgen exposureConclusionsThese preliminary findingsEstradiol levelsPostnatal exposurePregnant womenPrenatal exposureHormone levelsPostnatal testosterone levelsTestosterone levelsAndrogen hormonesAmniotic fluidLarger sample populationHormone effectsSteroid hormones