2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal life
2016
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
O'Donnell KJ, Meaney MJ. Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis. American Journal Of Psychiatry 2016, 174: 319-328. PMID: 27838934, DOI: 10.1176/appi.ajp.2016.16020138.BooksMeSH KeywordsAffectBirth WeightBrainChildChild, PreschoolChronic DiseaseFemaleFetal DevelopmentFetal Growth RetardationGene-Environment InteractionGlucocorticoidsHumansInfantInfant, NewbornMaleMaternal HealthMental DisordersNeurodevelopmental DisordersPregnancyPrenatal Exposure Delayed EffectsPsychopathologyRisk FactorsStress, PsychologicalTemperamentConceptsFetal growthMental healthFetal originLater psychopathologyMaternal mental healthDevelopmental originsNeurodevelopmental outcomesFetal neurodevelopmentChronic illnessObservational studyMaternal adversityMaternal anxietyStress mediatorsClinical relevanceFetal developmentPostnatal influencesAdult HealthDisease hypothesisFindings parallel studiesNeurodevelopmentGenetic factorsEmotional wellIllnessHealthRisk