2023
Maternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts.
Lähdepuro A, Räikkönen K, Pham H, Thompson-Felix T, Eid R, O'Connor T, Glover V, Lahti J, Heinonen K, Wolford E, Lahti-Pulkkinen M, O'Donnell K. Maternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts. Psychological Medicine 2023, 54: 1661-1670. PMID: 38087866, DOI: 10.1017/s0033291723003550.Peer-Reviewed Original ResearchChildren's cognitive abilitiesChildren's cognitive developmentGeneral cognitive abilityMaternal social supportCognitive abilitiesCognitive developmentSocial supportChildren's general cognitive abilitiesWechsler Intelligence ScaleMaternal experienceIntelligence ScaleTiming effectsAvon Longitudinal StudyMaternal anxietySensitive periodLongitudinal studyMaternal symptomsProspective longitudinal cohortAnxietyChildrenLess attentionDepressionLongitudinal cohortSupportWISCThe impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study.
Henry M, Chen L, Meaney M, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Deamond H, Lang J, Silver J, Ducharme L, Mascarella M, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. The impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study. Journal Of Clinical Oncology 2023, 41: 6063-6063. DOI: 10.1200/jco.2023.41.16_suppl.6063.Peer-Reviewed Original ResearchNeck cancerPolygenic risk scoresGenetic predispositionRisk scoreSuicidal ideationConsecutive adult patientsMedical chart reviewTreatment of patientsLongitudinal studyProspective longitudinal studyQuality of lifePost-treatment periodAdult patientsChart reviewPrimary HNCPrevious historyMedical variablesPatientsSaliva samplesLife compromiseCancerPast historyPsychosocial vulnerabilityGenetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry M, Harvey R, Chen L, Meaney M, Nguyen T, Kao H, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Greenwood C, Melnychuk D, Gold P, Chartier G, Black M, Mascarella M, MacDonald C, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. Journal Of Affective Disorders 2023, 331: 149-157. PMID: 36948466, DOI: 10.1016/j.jad.2023.03.007.Peer-Reviewed Original ResearchConceptsSymptom burdenNeck cancerGenetic predispositionPolygenic risk scoresRisk scoreAnxiety disordersImmediate post-treatment periodMedical chart reviewDose of radiotherapyStructured Clinical InterviewHigher polygenic risk scoreLongitudinal studyProspective longitudinal studyLife-threatening diseaseDose-related responsePost-treatment periodChart reviewHADS anxietyCancer survivalHigh prevalencePrimary headHigh riskDSM disordersPatientsClinical InterviewMaternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylationAssociations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Perret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples. Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.Peer-Reviewed Original ResearchDepressive symptomsSuicidal ideationEpigenome-wide DNA methylationHigh riskHigher depressive symptom scoresSelf-reported depressive symptomsDepressive symptom scoresTwo-cohort studyEpigenetic agingPopulation-based sampleEpigenetic indexBritish birth cohortChildhood peer victimizationQuebec Longitudinal StudySymptom scoresCohort 1Birth cohortSymptomsDNA methylation markersCohortPace of agingCandidate gene studiesLongitudinal studyIdeationMethylation markers
2022
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development
Perret LC, Boivin M, Morneau‐Vaillancourt G, Andlauer TFM, Paquin S, Langevin S, Girard A, Turecki G, O'Donnell K, Tremblay RE, Côté SM, Gouin J, Ouellet‐Morin I, Geoffroy M. Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development. Journal Of Child Psychology And Psychiatry 2022, 64: 388-396. PMID: 36124742, DOI: 10.1111/jcpp.13706.Peer-Reviewed Original ResearchConceptsDepressive symptomsGenetic predispositionQuebec Longitudinal StudyPolygenic risk scoresRisk scoreSelf-reported depressive symptomsLongitudinal studyIndividual genetic predispositionSuch gene-environment interactionsGene-environment interactionsSuch symptomsSymptomsDepressionChild developmentPredispositionAdolescencePeer victimisationFuture studiesEarly adolescenceScoresRiskAdolescentsAssociationMaternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood
O’Connor T, Ciesla AA, Sefair AV, Thornburg LL, Brown AS, Glover V, O’Donnell K. Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood. Journal Of Psychopathology And Clinical Science 2022, 131: 422-434. PMID: 35238594, PMCID: PMC9069845, DOI: 10.1037/abn0000746.Peer-Reviewed Original ResearchConceptsChild neurodevelopmentSelf-report questionnairesPrenatal maternal anxietyPrediction of symptomsAttention problemsMiddle childhoodCommunication problemsAnxiety symptomsPerson testingAvon Longitudinal StudyEmotional symptomsPrenatal anxietyPrenatal riskPrenatal maternal infectionMaternal anxietyAnxietyMental healthLongitudinal studyPrenatal infectionSeparate linesLine of studyLarge prospective longitudinal cohort studyProspective longitudinal cohort studyChild CohortNeurodevelopment
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2014
Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age
O'Donnell KJ, Glover V, Holbrook JD, O'Connor TG. Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age. Development And Psychopathology 2014, 26: 1255-1266. PMID: 25422959, DOI: 10.1017/s095457941400100x.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) genePrenatal maternal anxietyYears of agePrenatal anxietyBDNF polymorphismMaternal anxietyBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeInternalizing symptomsNeurotrophic factor geneAge 15 yearsAvon Longitudinal StudyMaternal prenatal anxietyMaternal symptomsChild internalizing symptomsGene-environment interactionsClinical InterviewPopulation cohortHealth outcomesSymptomsDiagnostic assessmentPsychosocial risksDifficulties QuestionnaireAge 13Longitudinal studyThe persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.Peer-Reviewed Original ResearchConceptsPrenatal anxietyMaternal moodPostnatal maternal moodLongitudinal studyMaternal prenatal anxietyLarge community samplePrenatal maternal moodOccasions of measurementPsychiatric symptomsChild mental disordersChild psychiatric symptomsEmotional problemsCommunity sampleAvon Longitudinal StudyEmotional symptomsChildhood psychopathologyPostnatal moodAge 4MoodAnxietyPersisting effectProgramming hypothesisMental disordersPrenatal depressionMajor modelsCortisol awakening response and subsequent depression: prospective longitudinal study
Carnegie R, Araya R, Ben-Shlomo Y, Glover V, O'Connor TG, O'Donnell KJ, Pearson R, Lewis G. Cortisol awakening response and subsequent depression: prospective longitudinal study. The British Journal Of Psychiatry 2014, 204: 137-143. PMID: 24311550, PMCID: PMC3909839, DOI: 10.1192/bjp.bp.113.126250.Peer-Reviewed Original ResearchConceptsCortisol awakening responseSubsequent depressionSalivary cortisolAwakening responseOdds ratioTime pointsICD-10 criteriaLongitudinal studyProspective longitudinal studyAvon Longitudinal StudyShort-term riskSubsequent depressive illnessLarge population cohortAdrenal functionDepressive illnessClinical significancePopulation cohortElevated cortisolCortisolLogistic regressionCortisol measuresStress reactivityDepressionDiurnal dropAssociation
2013
Stressful events and psychological difficulties: testing alternative candidates for sensitivity
Laceulle OM, O’Donnell K, Glover V, O’Connor T, Ormel J, van Aken MA, Nederhof E. Stressful events and psychological difficulties: testing alternative candidates for sensitivity. European Child & Adolescent Psychiatry 2013, 23: 103-113. PMID: 23756816, DOI: 10.1007/s00787-013-0436-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffective SymptomsAnxiety DisordersChildChild DevelopmentChild of Impaired ParentsChild, PreschoolDisease SusceptibilityFemaleHumansLife Change EventsMaleMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSex FactorsSocial EnvironmentSocioeconomic FactorsStress, PsychologicalSurveys and QuestionnairesTime FactorsConceptsPsychological difficultiesStressful eventsDifficult temperamentPrenatal anxietyLife eventsSources of sensitivityStressful life eventsPrenatal maternal anxietyChild developmentReciprocal associationsAge 7Maternal anxietyAge 4Child's ageTemperamentLongitudinal studyStress exposureAnxietyEarly childhoodCurrent studyConsistent evidenceChildrenPrior workDifficultiesAdditional researchPrenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort