2023
Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry M, Harvey R, Chen L, Meaney M, Nguyen T, Kao H, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Greenwood C, Melnychuk D, Gold P, Chartier G, Black M, Mascarella M, MacDonald C, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. Journal Of Affective Disorders 2023, 331: 149-157. PMID: 36948466, DOI: 10.1016/j.jad.2023.03.007.Peer-Reviewed Original ResearchConceptsSymptom burdenNeck cancerGenetic predispositionPolygenic risk scoresRisk scoreAnxiety disordersImmediate post-treatment periodMedical chart reviewDose of radiotherapyStructured Clinical InterviewHigher polygenic risk scoreLongitudinal studyProspective longitudinal studyLife-threatening diseaseDose-related responsePost-treatment periodChart reviewHADS anxietyCancer survivalHigh prevalencePrimary headHigh riskDSM disordersPatientsClinical InterviewAssociations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Perret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples. Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.Peer-Reviewed Original ResearchDepressive symptomsSuicidal ideationEpigenome-wide DNA methylationHigh riskHigher depressive symptom scoresSelf-reported depressive symptomsDepressive symptom scoresTwo-cohort studyEpigenetic agingPopulation-based sampleEpigenetic indexBritish birth cohortChildhood peer victimizationQuebec Longitudinal StudySymptom scoresCohort 1Birth cohortSymptomsDNA methylation markersCohortPace of agingCandidate gene studiesLongitudinal studyIdeationMethylation markers
2019
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children
Miguel PM, Pereira LO, Barth B, de Mendonça Filho EJ, Pokhvisneva I, Nguyen TTT, Garg E, Razzolini BR, Koh DXP, Gallant H, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP. Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children. Biological Psychiatry 2019, 86: 621-630. PMID: 31142432, DOI: 10.1016/j.biopsych.2019.03.983.Peer-Reviewed Original ResearchConceptsExpression-based polygenic risk scoreGray matter densityBrain gray matter densityPrefrontal cortexHypoxic-ischemic conditionsHistory of exposurePrefrontal cortex expressionExecutive functionIdentification of childrenHypoxia-ischemiaPerinatal complicationsHealthy childrenRisk factorsPolygenic risk scoresHigh riskRisk scoreDopamine reuptakeBirth cohortCortex expressionPoor oxygenationImpaired executive functionBrain developmentGenetic polymorphisms