Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depressionAssociations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children
Pantell M, Silveira P, de Mendonça Filho E, Wing H, Brown E, Keeton V, Pokhvisneva I, O’Donnell K, Neuhaus J, Hessler D, Meaney M, Adler N, Gottlieb L. Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children. Pediatric Research 2024, 95: 1553-1563. PMID: 38233512, PMCID: PMC11126389, DOI: 10.1038/s41390-023-02992-6.Peer-Reviewed Original ResearchSocial adversityChildhood social adversityBiomarkers of inflammationEpigenetic ageSocial risk factorsChildren aged 0ResultsOur final sampleCytokine clusterCumulative adversityFinal sampleSocial predictorsPediatric clinicAged 0Logistic regressionNeuroendocrine functionBiomarkers of stressRisk factorsImpactOur studySocial factorsU-shaped distributionAdversityAssociationBiomarker samplingChildhoodChildren