Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilities