Purification of serine racemase: Biosynthesis of the neuromodulator d-serine
Wolosker H, Sheth K, Takahashi M, Mothet J, Brady R, Ferris C, Snyder S. Purification of serine racemase: Biosynthesis of the neuromodulator d-serine. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 721-725. PMID: 9892700, PMCID: PMC15203, DOI: 10.1073/pnas.96.2.721.Peer-Reviewed Original ResearchConceptsBiosynthetic pathwayD-serine occursSerine racemaseAmino acidsD-serineMammalian brainNeuromodulator D-serineL-serineMolecular massSoluble enzymeEndogenous ligandPyridoxal phosphateRat brainN-methyl-D-aspartate receptorsEnzymeKm valuesRacemasePathwayHigh levelsRat cerebral cortexAspartate glutamate receptorsGlutamate receptorsRacemasesType II astrocytesGlial cultures