2024
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participants
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDementiaHumansMagnetic Resonance ImagingMiddle AgedNeuroimagingProspective StudiesSleep DurationStrokeWhite MatterConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionEffects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials
Salman R, Stephen J, Tierney J, Lewis S, Newby D, Parry-Jones A, White P, Connolly S, Benavente O, Dowlatshahi D, Cordonnier C, Viscoli C, Sheth K, Kamel H, Veltkamp R, Larsen K, Hofmeijer J, Kerkhoff H, Schreuder F, Shoamanesh A, Klijn C, van der Worp H, Haemorrhage C, Klug D, Casolla B, Puy L, Coffee M, Kuchcinski G, Labreuche J, van Nieuwenhuizen K, Algra A, van Gelder I, Kappelle L, Rinkel G, Schutgens R, Khatri P, Conwit R, Falcone G, Elm J, Anderson C, Song L, Pandian J, Hart R, Sharma M, Aref H, Tarhuni W, Fabregas J, Diener H, Endres M, Lemmens R, Kwon S, Lee B, Ameriso S, Milling T, Kasner S, Mikulik R, Xavier D, Beer R, Toni D, Eckstein J, Seiffge D, Ferro J, Tsivgoulis G, Sharma S, Wei-Liou C, Hohnloser S, Katsanos A, Bosch J, Healey J, Eikelboom J, Khaw A, Gladstone D, Pikula A, Coutts S, Smith E, Butcher K, Field T, Gioia L, Stapf C, Halse O, Ringleb P, Enzinger C, Sibon I, Montaner J, Caso V, Heuschmann P, Lip G, Haefeli W, Debette S, Dennis M, Wyller T, Rønning O, Eilertsen H, Ihle-Hansen H, Sandset E, Pennlert J, Glader E, Kruuse C, Wester P, Carlsson M, Forfang E. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials. The Lancet Neurology 2023, 22: 1140-1149. PMID: 37839434, DOI: 10.1016/s1474-4422(23)00315-0.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsAtrial FibrillationHumansIntracranial HemorrhagesProspective StudiesRandomized Controlled Trials as TopicStrokeConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsSpontaneous intracranial hemorrhageOral anticoagulationCardiovascular eventsIntracranial hemorrhageAtrial fibrillationCardiovascular deathIndividual participant dataEligible trialsHazard ratioPrimary outcomeOngoing trialsFixed-effect inverse variance modelParticipant dataDirect oral anticoagulantsOral anticoagulant agentsCochrane systematic reviewCox regression modelPrevious intracranial hemorrhageInverse variance modelBritish Heart FoundationLong-term useSubgroup of participantsAntiplatelet monotherapyIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson J, Gillet A, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas I, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer J, Armaignac D, Belden K, Kaufman M, Heavner S, Danesh V, Cheruku S, St. Hill C, Boman K, Deo N, Bansal V, Kumar V, Walkey A, Kashyap R, Mesland J, Henin P, Petre H, Buelens I, Gerard A, Clevenbergh P, Del Granado R, Mercado J, Vega-Terraza E, Iturricha-Caceres M, Garza R, Chu E, Chan V, Gavidia O, Pachon F, Kassas M, Tawheed A, Pineda E, Reyes Guillen G, Soto H, Vallecillo Lizardo A, Segu S, Chakraborty T, Joyce E, Kasumalla P, Vadgaonkar G, Ediga R, Basety S, Dammareddy S, Raju U, Manduva J, Kolakani N, Sripathi S, Chaitanya S, Cherian A, Parameswaran S, Parthiban M, Menu P, Daga M, Agarwal M, Rohtagi I, Papani S, Kamuram M, Agrawal K, Baghel V, Patel K, Mohan S, Jyothisree E, Dalili N, Nafa M, Matsuda W, Suzuki R, Sanui M, Horikita S, Itagaki Y, Kodate A, Takahashi Y, Moriki K, Shiga T, Iwasaki Y, Rodriguez-Gutierrez R, Gonzale J, Salcido-Montenegro A, Camacho-Ortiz A, Hassan-Hanga F, Galadanci H, Gezawa A, Kabir H, Amole T, Haliru D, Ibrahim A, Asghar M, Syed M, Naqvi S, Zabolotskikh I, Musaeva T, Alamoudi R, AlSharif H, Almazwaghi S, Elsakran M, Aid M, Darwich M, Hagag O, Ali S, Rocacorba A, Supena K, Juane E, Medina J, Baduria J, Amer M, Bawazeer M, Dahhan T, Kseibi E, Butt A, Khurshid S, Rabee M, Abujazar M, Alghunaim R, Abualkhair M, AlFirm A, Almazyad M, Alarifi M, Macarambon J, Bukhari A, Albahrani H, Asfina K, Aldossary K, Zoran M, Popadic V, Klasnja S, Bojicic J, Kovacevic B, Predrag S, Stojakov D, Ignjatovic D, Bojicic S, Bobos M, Nenadic I, Zaric M, Djuric M, Djukic V, Teruel S, Martin B, Sili U, Bilgin H, Ay P, Dodd K, Goodmanson N, Hesse K, Bird P, Weinert C, Schoenrade N, Altaher A, Mayar E, Aronson M, Cooper T, Logan M, Miner B, Papo G, Siegal E, Runningen P, Patel L, Melamed R, Tierney D, Raj V, Mazumder N, Hill C, Kirkland L, Schmitz N, Sigman A, Hall J, Raval A, Franks A, Jarvis J, Kharbanda A, Jhajhria S, Fyffe Z, Capizzi S, Alicie B, Green M, Corckarell L, Drennan A, Dubuque K, Fambrough T, Gasaway N, Krantz B, Nebi P, Orga J, Serfass M, Simion A, Warren K, Wheeler C, Woolman C, Christie A, Ashley D, Adiga R, Moyer A, Verghese G, Sikora Newsome A, Forehand C, Bruning R, Jones T, Sabov M, Zaidi F, Tissavirasingham F, Malipeddi D, Mosier J, Lutrick K, Campbell B, Wilson C, Rivers P, Brinks J, Ndiva Mongoh M, Gilson B, Armaignac D, Parris D, Zuniga M, Vargas I, Boronat V, Hutton A, Kaur N, Neupane P, Sadule-Rios N, Rojas L, Neupane A, Rivera P, Valle Carlos C, Vincent G, Amin M, Schelle M, Steadham A, Howard C, McBride C, Abraham J, Garner O, Richards K, Collins K, Antony P, Mathew S, Danesh V, Dubrocq G, Davis A, Hammers M, McGahey I, Farris A, Priest E, Korsmo R, Fares L, Skiles K, Shor S, Burns K, Flores M, Newman L, Wilk D, Ettlinger J, Bomar J, Darji H, Arroliga A, Dowell C, Gonzales G, Flores M, Walkey A, Waikar S, Garcia M, Colona M, Kibbelaar Z, Leong M, Wallman D, Soni K, Maccarone J, Gilman J, Devis Y, Chung J, Paracha M, Lumelsky D, DiLorenzo M, Abdurrahman N, Johnson S, Hersh M, Wachs S, Swigger B, Sattler L, Moulton M, Zammit K, McGrath P, Loeffler W, Chilbert M, Tirupathi R, Tang A, Safi A, Green C, Newell J, Ramani N, Ganti B, Ihle R, Davis E, Martin S, Sayed I, Gist K, Strom L, Chiotos K, Blatz A, Lee G, Burnett R, Sydney G, Traynor D, Surani S, White J, Khan A, Dhahwal R, Cheruku S, Ahmed F, Deonarine C, Jones A, Shaikh M, Preston D, Chin J, Vachharajani V, Duggal A, Rajendram P, Mehkri O, Dugar S, Biehl M, Sacha G, Houltham S, Kind A, Ashok K, Poynter B, Beukemann M, Rice R, Gole S, Shaner V, Conjeevaram A, Ferrari M, Alappan N, Minear S, Hernandez-Montfort J, Nasim S, Sunderkrishnan R, Sahoo D, Milligan P, Gupta S, Koglin J, Gibson R, Johnson L, Preston F, Scott C, Nungester B, Byrne D, Schorr C, Grant K, Doktar K, Porto M, Kaplan O, Siegler J, Schonewald B, Woodford A, Tsai A, Reid S, Bhowmick K, Daneshpooy S, Mowdawalla C, Dave T, Connor Crudeli W, Ferry C, Nguyen L, Modi S, Padala N, Patel P, Lin B, Qiuyun J, Liu F, Kota R, Banerjee A, Daugherty S, Atkinson S, Shrimpton K, Ontai S, Contreras B, Obinwanko U, Amamasi N, Sharafi A, Lee S, Esber Z, Jinjvadia C, Bartz R, Krishnamoorthy V, Kraft B, Pulsipher A, Friedman E, Mehta S, Kaufman M, Lobel G, Gandhi N, Abdelaty A, Shaji E, Lim K, Marte J, Sosa D, Yamane D, Benjenk I, Prasanna N, Perkins N, Roth P, Litwin A, Pariyadath A, Moschella P, Llano T, Waller C, Kallies K, Thorsen J, Fitzsimmons A, Olsen H, Smalls N, Davis S, Jovic V, Masuda M, Hayes A, Nault K, Smith M, Snow W, Liptak R, Durant H, Pendleton V, Nanavati A, Mrozowsk R, Doubleday E, Liu Y, Zavala S, Shim E, Reilkoff R, Heneghan J, Eichen S, Goertzen L, Rajala S, Feussom G, Tang B, Junia C, Lichtenberg R, Sidhu H, Espinoza D, Rodrigues S, Zabala M, Goyes D, Susheela A, Hatharaliyadda B, Rameshkumar N, Kasireddy A, Maldonado G, Beltran L, Chaugule A, Khan H, Patil N, Patil R, Cartin-Ceba R, Sen A, Talaei F, Kashyap R, Pablo Domecq J, Gajic O, Bansal V, Tekin A, Lal A, O'Horo J, Deo N, Sharma M, Qamar S, Singh R, Valencia Morales D, La Nou A, Bogojevic M, Zec S, Sanghavi D, Guru P, Morno Franco P, Ganaphadithan K, Saunders H, Fleissner Z, Garcia J, Yu Lee Mateus A, Yarrarapu S, Kaur N, Giri A, Mustafa Hasan M, Donepudi A, Khan S, Jain N, Koritala T, Nanchal R, Bergl P, Peterson J, Yamanaka T, Barreras N, Markos M, Fareeduddin A, Mehta R, Venkata C, Engemann M, Mantese A, Tarabichi Y, Perzynski A, Wang C, Kotekal D, Briceno Bierwirth A, Orellana G, Catalasan G, Ahmed S, Matute C, Hamdan A, Salinas I, Nogal G, Tejada A, Chen J, Hope A, Tsagaris Z, Ruen E, Hambardzumyan A, Siddiqi N, Jurado L, Tincher L, Brown C, Aulakh B, Tripathi S, Bandy J, Kreps L, Bollinger D, Scott Stienecker R, Melendez A, Brunner T, Budzon S, Heffernan J, Souder J, Miller T, Maisonneuve A, Redfern R, Shoemaker J, Micham J, Kenney L, Naimy G, J Pulver K, Yehle J, Weeks A, Inman T, Delmonaco B, Franklin A, Heath M, Vilella A, Kutner S, Clark K, Moore D, Anderson H, Rajkumar D, Abunayla A, Heiter J, Zaren H, Smith S, Lewis G, Seames L, Farlow C, Miller J, Broadstreet G, Martinez A, Allison M, Mittal A, Ruiz R, Skaanland A, Ross R, Patel U, Hodge J, Patel K, Dalal S, Kavani H, Joseph S, Bernstein M, Goff I, Naftilan M, Mathew A, Williams D, Murdock S, Ducey M, Nelson K, Block J, Mitchel J, O'Brien C, Cox S, Amzuta I, Shah A, Modi R, Al-Khalisy H, Masuta P, Schafer M, Wratney A, Carter K, Olmos M, Parker B, Quintanilla J, Craig T, Clough B, Jameson J, Gupta N, Jones T, Ayers S, Harrell A, Brown B, Darby C, Page K, Brown A, McAbee J, Belden K, Baram M, Weber D, DePaola R, Xia Y, Carter H, Tolley A, Ferranti M, Steele M, Kemble L, Sethi J, Cheng Han C, Pagliaro J, Husian A, Malhotra A, Zawaydeh Q, Sines B, Bice T, Markotic D, Bosnjak I, Vail E, Nicholson S, Jonas R, Dement A, Tang W, DeRose M, Villarreal R, Dy R, Lardino A, Sharma J, Czieki R, Christopher J, Lacey R, Mashina M, Patel K, Gomaa D, Goodman M, Wakefield D, Spuzzillo A, Shinn II J, Bihorac A, Ozrazgat Baslanti T, Omalay G, Hashemighouchani H, Cupka J, Ruppert M, McGonagill P, Galet C, Hubbard J, Wang D, Allan L, Badheka A, Chegondi M, Nazir U, Rampon G, Riggle J, Dismag N, Akca O, Lenhardt R, Cavallazzi R, Jerde A, Black A, Polidori A, Griffey H, Winkler J, Brenzel T, Alvarez R, Alarocon-Calderon A, Sosa M, Mahabir S, Patel M, Parker P, Admon A, Hanna S, Chanderraj R, Pliakas M, Wolski A, Cirino J, Dandachi D, Regunath H, Camazine M, Geiger G, Njai A, Saad B, Shah F, Chuan B, Rawal S, Piracha M, Tonna J, Levin N, Suslavich K, Tsolinas R, Fica Z, Skidmore C, Stapleton R, Dixon A, Johnson O, Ardren S, Burns S, Raymond A, Gonyaw E, Hodgdon K, Houseger C, Lin B, McQuesten K, Pecott- Grimm H, Sweet J, Ventrone S, Khandelwal N, West T, Caldwell E, Lovelace-Macon L, Garimella N, Dow D, Akhter M, Rahman R, Mulrow M, Wilfong E, Vela K, Khanna A, Harris L, Cusson B, Fowler J, Vaneenenaam D, Mckinney G, Udoh I, Johnson K, Lyons P, Michelson A, Haulf S, Lynch L, Nguyen N, Steinbery A, Braus N, Pattan V, Papke J, Jimada I, Mhid N, Chakola S, Sheth K, Ammar A, Ammar M, Lopez V, Dela Cruz C, Khosla A, Gautam S. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Network Open 2021, 4: e2140568. PMID: 34935924, PMCID: PMC8696573, DOI: 10.1001/jamanetworkopen.2021.40568.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeRisk of ARDSLength of stayInvasive mechanical ventilationMetabolic syndrome criteriaMetabolic syndromeRespiratory distress syndromeSyndrome criteriaDistress syndromeMechanical ventilationCOVID-19ICU LOSIntensive care unit admissionHospital LOSSARS-CoV-2 infectionCare unit admissionMulticenter cohort studySevere COVID-19Hospital mortalityUnit admissionICU admissionAdult patientsCohort studyCommon comorbiditiesControl patients
2019
Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial
Selim M, Foster L, Moy C, Xi G, Hill M, Morgenstern L, Greenberg S, James M, Singh V, Clark W, Norton C, Palesch Y, Yeatts S, Investigators I, Dolan M, Yeh E, Sheth K, Kunze K, Muehlschlegel S, Nieto I, Claassen J, Falo C, Huang D, Beckwith A, Messe S, Yates M, O'Phelan K, Escobar A, Becker K, Tanzi P, Gonzales N, Tremont C, Venkatasubramanian C, Thiessen R, Save S, Verrault S, Collard K, DeGeorgia M, Cwiklinski V, Thompson B, Wasilewski L, Andrews C, Burfeind R, Torbey M, Hamed M, Butcher K, Sivakumar L, Varelas N, Mays-Wilson K, Leira E, Olalde H, Silliman S, Calhoun R, Dangayach N, Renvill R, Malhotra R, Kordesch K, Lord A, Calahan T, Geocadin R, Parish M, Frey J, Harrigan M, Leifer D, Mathias R, Schneck M, Bernier T, Gonzales-Arias S, Elysee J, Lopez G, Volgi J, Brown R, Jasak S, Phillips S, Jarrett J, Gomes J, McBride M, Aldrich F, Aldrich C, Kornbluth J, Bettle M, Goldstein J, Tirrell G, Shaw Q, Jonczak K. Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial. The Lancet Neurology 2019, 18: 428-438. PMID: 30898550, PMCID: PMC6494117, DOI: 10.1016/s1474-4422(19)30069-9.Peer-Reviewed Original ResearchConceptsBetter clinical outcomesPhase 2 trialSerious adverse eventsRankin Scale scorePlacebo groupIntracerebral hemorrhagePrimary outcomeClinical outcomesDay 90Deferoxamine mesylateModified intentionTreat populationAdverse eventsUS National InstitutesDouble-blind phase 2 trialScale scorePhase 3 efficacy trialsModified Rankin Scale scoreEfficacy of deferoxaminePhase 3 trialSupratentorial intracerebral hemorrhageAbsolute risk differenceProportion of participantsNational InstituteIron chelator deferoxamine
2013
Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke
Sheth KN, Kimberly WT, Elm JJ, Kent TA, Mandava P, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, Simard JM, Stern BJ. Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke. Stroke 2013, 45: 281-283. PMID: 24193798, PMCID: PMC4235339, DOI: 10.1161/strokeaha.113.003352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood GlucoseBrain EdemaBrain IschemiaComorbidityFemaleFibrinolytic AgentsGlyburideHumansHypoglycemiaHypoglycemic AgentsInjections, IntravenousMagnetic Resonance ImagingMaleMiddle AgedPatient SafetyPilot ProjectsProspective StudiesStrokeTissue Plasminogen ActivatorTreatment OutcomeWhite PeopleYoung AdultConceptsIschemic strokeLesion volumeIntravenous recombinant tissue-type plasminogen activatorRecombinant tissue-type plasminogen activatorIpsilateral hemisphere volumeLarge ischemic strokeSerious adverse eventsAcute ischemic strokeRetrospective clinical dataFeasibility of recruitingTissue-type plasminogen activatorIntravenous glyburideSevere strokeSymptomatic hypoglycemiaAdverse eventsFocal ischemiaMean ageClinical trialsHemisphere volumeClinical dataDose reductionAge 18PatientsSulfonylurea receptorPlasminogen activator
2012
Intracranial Pressure Dose and Outcome in Traumatic Brain Injury
Sheth KN, Stein DM, Aarabi B, Hu P, Kufera JA, Scalea TM, Hanley DF. Intracranial Pressure Dose and Outcome in Traumatic Brain Injury. Neurocritical Care 2012, 18: 26-32. PMID: 23055087, DOI: 10.1007/s12028-012-9780-3.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryElevated intracranial pressureBrain injuryIntracranial pressureFunctional outcomeExtended Glasgow Outcome ScaleCenter observational studyCornerstone of managementGlasgow Outcome ScalePoor functional outcomeIntracranial pressure measurementClinical outcomesOutcome ScaleUniversity HospitalObservational studyProspective patientsCandidate biomarkersInjuryTime doseConclusionsThese resultsOutcomesPatientsMortalityDose
1996
Admission Serum Magnesium Level Does Not Predict the Hospital Outcome of Patients With Acute Myocardial Infarction
Madias J, Sheth K, Choudry M, Berger D, Madias N. Admission Serum Magnesium Level Does Not Predict the Hospital Outcome of Patients With Acute Myocardial Infarction. JAMA Internal Medicine 1996, 156: 1701-1708. PMID: 8694669, DOI: 10.1001/archinte.1996.00440140135013.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSerum magnesium concentrationSerum magnesium levelsMyocardial infarctionHospital courseEmergency departmentDiuretic agentsEarly presentationMagnesium levelsLow serum magnesium concentrationsAdmission serum magnesium levelsNormal serum magnesium concentrationsPatient's hospital courseOnset of symptomsCoronary care unitMagnesium concentrationHigh rateHypomagnesemic patientsNormomagnesemic patientsPreadmission useCardiac mortalityHospital outcomesExcessive morbidityAntiarrhythmic drugsCare unit