2023
Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke
Samaniego E, Boltze J, Lyden P, Hill M, Campbell B, Silva G, Sheth K, Fisher M, Hillis A, Nguyen T, Carone D, Favilla C, Deljkich E, Albers G, Heit J, Lansberg M, Aksoy D, Broderick J, Castonguay A, Ghosh S, Grotta J, Harston G, Houser G, Kuchenbecker K, Latour L, Liebeskind D, Kylan Lynch J, Maier C, Mistry E, Mocco J, Nogueira R, Saver J, van Vlimmeren M, Wakhloo A, Wechsler L. Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke. Stroke 2023, 54: 3190-3201. PMID: 37942645, PMCID: PMC10841844, DOI: 10.1161/strokeaha.123.044985.Peer-Reviewed Original ResearchConceptsAcute strokeDiagnostic workupAcute ischemic stroke treatmentAcute ischemic strokeComprehensive stroke centerHigh-resolution vessel wallCerebral Infarction (TICI) scaleIschemic stroke treatmentMobile stroke unitIschemic strokeStroke centersStroke treatmentStroke unitReperfusion outcomesPatient outcomesEarly ischemiaCone beamStrokeVessel wallWorkupAcademic investigatorsOutcomesTomographyThrombolysisReperfusion
2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A, Siddiqui S, Sheth K, Matouk C, Cruz C, Zhou J, Dawson V, Dawson T, Liang J, van Zijl P, Zeiler S, Taylor Kimberly W, Erdogan T, Yu L, Mandeville J, Whittier J. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke 2022, 53: 1802-1812. PMID: 35354299, PMCID: PMC9038686, DOI: 10.1161/strokeaha.121.038047.Peer-Reviewed Original ResearchConceptsPreclinical assessmentStroke treatmentCandidate treatmentMiddle cerebral artery occlusion (MCAO) surgeryClinical stroke trialsSuccessful stroke treatmentInclusion/exclusion criteriaStroke clinical trialsClinical trial designYoung male animalsComorbid diseasesOcclusion surgeryCerebral ischemiaNeurological disabilityComorbid conditionsStroke trialsProtocol adherenceBlinded assessmentSuch therapyClinical trialsClinical studiesExclusion criteriaTrial designAged animalsOutcome assessment
2021
Race/Ethnicity Considerations in the Prevention and Treatment of Stroke
Forman R, Sheth K. Race/Ethnicity Considerations in the Prevention and Treatment of Stroke. Current Treatment Options In Neurology 2021, 23: 33. DOI: 10.1007/s11940-021-00684-2.Peer-Reviewed Original ResearchStroke risk factorsGreater Cincinnati/Northern Kentucky Stroke StudyRisk factorsBlack individualsRate of strokeHospital arrival timeWhite individualsTreatment of strokeRecent FindingsMultiple studiesPurpose of ReviewToHigh mortality rateStroke outcomeHemorrhagic strokeStroke treatmentWhite patientsBlack patientsStroke disparitiesStroke patientsStroke StudyTimely treatmentMortality rateGreater incidenceGreater severityEthnic disparitiesStrokeTop Priorities for Cerebroprotective Studies—A Paradigm Shift
Lyden P, Buchan A, Boltze J, Fisher M, Ansari S, Broderick J, Campbell B, Chaisinanunkul N, Chen C, Grotta J, Haddad W, Hareedy R, Hill M, Houser G, Jadhav A, Khatri P, Kimberly W, Koenig J, Korinek W, Landen J, Lansberg M, Latour L, Liebeskind D, Liston T, Lynch J, McGonigle J, Mistry E, Mocco J, Pryor K, Saver J, Savitz S, Sheth K, Solberg Y, Vagal A, Venkatasubramanian C, Ziogas N. Top Priorities for Cerebroprotective Studies—A Paradigm Shift. Stroke 2021, 52: 3063-3071. PMID: 34289707, PMCID: PMC8384700, DOI: 10.1161/strokeaha.121.034947.Peer-Reviewed Original ResearchConceptsComprehensive preclinical assessmentPreclinical assessmentNeurovascular unitMajor public health concernSalvageable brain tissueStroke symptom onsetIschemic stroke treatmentBlood-brain barrierConsensus-based recommendationsPharmacokinetics/pharmacodynamicsClinical trial designPaucity of evidencePublic health concernDifferent brain regionsMechanism of actionCerebroprotective agentTerm neuroprotectionIschemic strokeSymptom onsetStroke treatmentClinical outcomesComorbid conditionsCore injuryClinical trialsStroke modelThe state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys
Owolabi M, Thrift A, Martins S, Johnson W, Pandian J, Abd-Allah F, Varghese C, Mahal A, Yaria J, Phan H, Roth G, Gall S, Beare R, Phan T, Mikulik R, Norrving B, Feigin V, Abera S, Addissie A, Adeleye A, Adilbekov Y, Adilbekova B, Adoukonou T, Aguiar D, Akhmetzhanova Z, Akinyemi R, Akpalu A, Ameriso S, Andonova S, Abanto C, Awoniyi F, Bakhiet M, Basri H, Bath P, Bereczki D, Beretta S, Berkowitz A, Bernhardt J, Berzina G, Bhavsar B, Bisharyan M, Bovet P, Brainin M, Budincevic H, Cabral N, Cadilhac D, Caso V, Chen C, Chin J, Christensen H, Chwojnicki K, Conforto A, Cruz V, D'Amelio M, Danielyan K, Davis S, Demarin V, Dempsey R, Dichgans M, Dokova, Donnan G, Duran J, Elizondo M, Elkind M, Endres M, Etedal I, Faris M, Fischer U, Gankpe F, Gavidia M, Gaye-Saavedra A, Giroud M, Gongora-Rivera F, Hachinski V, Hacke W, Hamadeh R, Hamzat T, Hankey G, Heldner M, Ibrahim N, Inoue M, Jee S, Jiann-Shing J, Johnston S, Kalkonde Y, Kamenova S, Kelly P, Khan T, Kiechl S, Kondybayeva A, Kõrv J, Kravchenko M, Krishnamurthi R, Langhorne P, Kang Z, Kruja J, Lavados P, Lebedynets D, Leung T, Liebeskind D, Lindsay P, Liu L, López-Jaramillo P, Lotufo P, Machline-Carrion J, Markus H, Marquez-Romero J, Medina M, Medukhanova S, Mehndiratta M, Mirrakhimov E, Mohl S, Murphy S, Musa K, Nasreldein A, Nogueira R, Nolte C, Norrving B, Noubiap J, Novarro-Escudero N, O'Donnell M, Ogun V, Oraby M, Ovbiagele B, Ōrken D, Ōzdemir A, Ozturk S, Paccot M, Peters A, Piradov M, Platz T, Potpara T, Ranta A, Rathore F, Roth G, Sacco R, Sahathevan R, Santos I, Saposnik G, Sarfo F, Sharma M, Sheth K, Shobhana A, Silva S, Suwanwela N, Sylaja P, Thakur K, Toni D, Topcuoglu M, Torales J, Towfighi A, Truelsen T, Tsiskaridze A, Tsong-Hai L, Tulloch-Reid M, Useche J, Vanacker P, Vassilopoulou S, Venketasubramanian N, Vukorepa G, Vuletic V, Wahab K, Wang W, Wijeratne T, Wolfe C, Yifru M, Yock-Corrales A, Yonemoto N, Yperzeele L. The state of stroke services across the globe: Report of World Stroke Organization–World Health Organization surveys. International Journal Of Stroke 2021, 16: 889-901. PMID: 33988062, PMCID: PMC8800855, DOI: 10.1177/17474930211019568.Peer-Reviewed Original ResearchConceptsStroke servicesHigh-income countriesStroke burdenStroke unitLow-income countriesAcute stroke care servicesHealth OrganizationGlobal stroke burdenHospital discharge programAcute stroke treatmentStroke care servicesWorld Health Organization (WHO) regionsNon-communicable diseasesOverall global scoresWorld Health OrganizationMiddle-income countriesStroke treatmentRehabilitation protocolInterdisciplinary careStroke rehabilitationHome assessmentPatient rehabilitationCare servicesDischarge programRehabilitation servicesRace/ethnicity and Insurance Status Impact Acute Ischemic Stroke Treatment within Three Large U.S. States (2968)
Herman A, Kuohn L, Falcone G, Sharma R, Hwang D, Sheth K, Kim J. Race/ethnicity and Insurance Status Impact Acute Ischemic Stroke Treatment within Three Large U.S. States (2968). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2968.Peer-Reviewed Original Research