2024
Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials
de Havenon A, Viscoli C, Kleindorfer D, Sucharew H, Delic A, Becker C, Robinson D, Yaghi S, Li V, Lansberg M, Cramer S, Mistry E, Sarpong D, Kasner S, Kernan W, Sheth K. Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials. JAMA Network Open 2024, 7: e2423677. PMID: 39028666, PMCID: PMC11259901, DOI: 10.1001/jamanetworkopen.2024.23677.Peer-Reviewed Original ResearchConceptsPrevention trialsPoststroke disabilityRecurrent stroke ratesRecurrent strokeCohort studyRate of recurrent strokeStroke Prevention TrialIncreased hazardInsulin Resistance InterventionSecondary prevention trialsBaseline disabilityAssociated with increased ratesStroke rateMain OutcomesFunctional statusResistance InterventionStudy baselineSecondary outcomesPrimary outcomeWorsening heart failureModified Rankin ScaleProfession's participationLong-term followVascular deathDisabilityEndovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States
de Havenon A, Zhou L, Koo A, Matouk C, Falcone G, Sharma R, Ney J, Shu L, Yaghi S, Kamel H, Sheth K. Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States. JAMA Neurology 2024, 81: 264-272. PMID: 38285452, PMCID: PMC10825786, DOI: 10.1001/jamaneurol.2023.5416.Peer-Reviewed Original ResearchNational Institutes of Health Stroke ScaleNational Institutes of Health Stroke Scale scoreOdds of discharge homeDischarged homeIschemic strokeRate of endovascular thrombectomyMultivariate logistic regressionNational Inpatient Sample databaseHealth Stroke ScaleIntervention patientsInpatient Sample databaseMain OutcomesIntervention statusHospitalization of patientsPotential confoundersUS hospitalsEndovascular thrombectomyStroke patientsCohort studySecondary outcomesLogistic regressionCardiac interventionsStroke severityStroke ScaleGroup of hospitalized patientsTime to Anticoagulation Reversal and Outcomes After Intracerebral Hemorrhage
Sheth K, Solomon N, Alhanti B, Messe S, Xian Y, Bhatt D, Hemphill J, Frontera J, Chang R, Danelich I, Huang J, Schwamm L, Smith E, Goldstein J, Mac Grory B, Fonarow G, Saver J. Time to Anticoagulation Reversal and Outcomes After Intracerebral Hemorrhage. JAMA Neurology 2024, 81: 363-372. PMID: 38335064, PMCID: PMC11002694, DOI: 10.1001/jamaneurol.2024.0221.Peer-Reviewed Original ResearchDoor-to-treatment timeDoor-to-treatmentUS hospitalsQuality improvement registryOnset-to-treatment timeAmerican Heart AssociationFunctional outcomesLogistic regression modelsAssociated with decreased mortalityGuidelines-StrokeIntracerebral hemorrhageHospital characteristicsImprovement registryIntervention statusMain OutcomesAnticoagulation-associated intracerebral hemorrhageSystolic blood pressureInpatient mortalityRandom interceptCohort studyWhite raceSecondary outcomesStroke subtypesStroke severityWorkflow times
2023
Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
Simonetto M, Sheth K, Ziai W, Iadecola C, Zhang C, Murthy S. Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage. Stroke 2023, 54: 2401-2408. PMID: 37462054, PMCID: PMC10529487, DOI: 10.1161/strokeaha.123.043160.Peer-Reviewed Original ResearchConceptsNon-Hispanic white patientsNon-Hispanic blacksIschemic strokeIntracerebral hemorrhageHispanic patientsWhite patientsAtrial fibrillationICH patientsHigh riskNon-Hispanic black patientsCox proportional hazards modelIncident ischemic strokeRetrospective cohort studyNontraumatic intracerebral hemorrhageValvular heart diseaseTime of dischargeLarge heterogeneous cohortProportional hazards modelNon-Hispanic whitesICH hospitalizationsCardiovascular comorbiditiesMedian followCohort studyVascular comorbiditiesConcomitant diagnosis
2021
Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson J, Gillet A, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas I, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer J, Armaignac D, Belden K, Kaufman M, Heavner S, Danesh V, Cheruku S, St. Hill C, Boman K, Deo N, Bansal V, Kumar V, Walkey A, Kashyap R, Mesland J, Henin P, Petre H, Buelens I, Gerard A, Clevenbergh P, Del Granado R, Mercado J, Vega-Terraza E, Iturricha-Caceres M, Garza R, Chu E, Chan V, Gavidia O, Pachon F, Kassas M, Tawheed A, Pineda E, Reyes Guillen G, Soto H, Vallecillo Lizardo A, Segu S, Chakraborty T, Joyce E, Kasumalla P, Vadgaonkar G, Ediga R, Basety S, Dammareddy S, Raju U, Manduva J, Kolakani N, Sripathi S, Chaitanya S, Cherian A, Parameswaran S, Parthiban M, Menu P, Daga M, Agarwal M, Rohtagi I, Papani S, Kamuram M, Agrawal K, Baghel V, Patel K, Mohan S, Jyothisree E, Dalili N, Nafa M, Matsuda W, Suzuki R, Sanui M, Horikita S, Itagaki Y, Kodate A, Takahashi Y, Moriki K, Shiga T, Iwasaki Y, Rodriguez-Gutierrez R, Gonzale J, Salcido-Montenegro A, Camacho-Ortiz A, Hassan-Hanga F, Galadanci H, Gezawa A, Kabir H, Amole T, Haliru D, Ibrahim A, Asghar M, Syed M, Naqvi S, Zabolotskikh I, Musaeva T, Alamoudi R, AlSharif H, Almazwaghi S, Elsakran M, Aid M, Darwich M, Hagag O, Ali S, Rocacorba A, Supena K, Juane E, Medina J, Baduria J, Amer M, Bawazeer M, Dahhan T, Kseibi E, Butt A, Khurshid S, Rabee M, Abujazar M, Alghunaim R, Abualkhair M, AlFirm A, Almazyad M, Alarifi M, Macarambon J, Bukhari A, Albahrani H, Asfina K, Aldossary K, Zoran M, Popadic V, Klasnja S, Bojicic J, Kovacevic B, Predrag S, Stojakov D, Ignjatovic D, Bojicic S, Bobos M, Nenadic I, Zaric M, Djuric M, Djukic V, Teruel S, Martin B, Sili U, Bilgin H, Ay P, Dodd K, Goodmanson N, Hesse K, Bird P, Weinert C, Schoenrade N, Altaher A, Mayar E, Aronson M, Cooper T, Logan M, Miner B, Papo G, Siegal E, Runningen P, Patel L, Melamed R, Tierney D, Raj V, Mazumder N, Hill C, Kirkland L, Schmitz N, Sigman A, Hall J, Raval A, Franks A, Jarvis J, Kharbanda A, Jhajhria S, Fyffe Z, Capizzi S, Alicie B, Green M, Corckarell L, Drennan A, Dubuque K, Fambrough T, Gasaway N, Krantz B, Nebi P, Orga J, Serfass M, Simion A, Warren K, Wheeler C, Woolman C, Christie A, Ashley D, Adiga R, Moyer A, Verghese G, Sikora Newsome A, Forehand C, Bruning R, Jones T, Sabov M, Zaidi F, Tissavirasingham F, Malipeddi D, Mosier J, Lutrick K, Campbell B, Wilson C, Rivers P, Brinks J, Ndiva Mongoh M, Gilson B, Armaignac D, Parris D, Zuniga M, Vargas I, Boronat V, Hutton A, Kaur N, Neupane P, Sadule-Rios N, Rojas L, Neupane A, Rivera P, Valle Carlos C, Vincent G, Amin M, Schelle M, Steadham A, Howard C, McBride C, Abraham J, Garner O, Richards K, Collins K, Antony P, Mathew S, Danesh V, Dubrocq G, Davis A, Hammers M, McGahey I, Farris A, Priest E, Korsmo R, Fares L, Skiles K, Shor S, Burns K, Flores M, Newman L, Wilk D, Ettlinger J, Bomar J, Darji H, Arroliga A, Dowell C, Gonzales G, Flores M, Walkey A, Waikar S, Garcia M, Colona M, Kibbelaar Z, Leong M, Wallman D, Soni K, Maccarone J, Gilman J, Devis Y, Chung J, Paracha M, Lumelsky D, DiLorenzo M, Abdurrahman N, Johnson S, Hersh M, Wachs S, Swigger B, Sattler L, Moulton M, Zammit K, McGrath P, Loeffler W, Chilbert M, Tirupathi R, Tang A, Safi A, Green C, Newell J, Ramani N, Ganti B, Ihle R, Davis E, Martin S, Sayed I, Gist K, Strom L, Chiotos K, Blatz A, Lee G, Burnett R, Sydney G, Traynor D, Surani S, White J, Khan A, Dhahwal R, Cheruku S, Ahmed F, Deonarine C, Jones A, Shaikh M, Preston D, Chin J, Vachharajani V, Duggal A, Rajendram P, Mehkri O, Dugar S, Biehl M, Sacha G, Houltham S, Kind A, Ashok K, Poynter B, Beukemann M, Rice R, Gole S, Shaner V, Conjeevaram A, Ferrari M, Alappan N, Minear S, Hernandez-Montfort J, Nasim S, Sunderkrishnan R, Sahoo D, Milligan P, Gupta S, Koglin J, Gibson R, Johnson L, Preston F, Scott C, Nungester B, Byrne D, Schorr C, Grant K, Doktar K, Porto M, Kaplan O, Siegler J, Schonewald B, Woodford A, Tsai A, Reid S, Bhowmick K, Daneshpooy S, Mowdawalla C, Dave T, Connor Crudeli W, Ferry C, Nguyen L, Modi S, Padala N, Patel P, Lin B, Qiuyun J, Liu F, Kota R, Banerjee A, Daugherty S, Atkinson S, Shrimpton K, Ontai S, Contreras B, Obinwanko U, Amamasi N, Sharafi A, Lee S, Esber Z, Jinjvadia C, Bartz R, Krishnamoorthy V, Kraft B, Pulsipher A, Friedman E, Mehta S, Kaufman M, Lobel G, Gandhi N, Abdelaty A, Shaji E, Lim K, Marte J, Sosa D, Yamane D, Benjenk I, Prasanna N, Perkins N, Roth P, Litwin A, Pariyadath A, Moschella P, Llano T, Waller C, Kallies K, Thorsen J, Fitzsimmons A, Olsen H, Smalls N, Davis S, Jovic V, Masuda M, Hayes A, Nault K, Smith M, Snow W, Liptak R, Durant H, Pendleton V, Nanavati A, Mrozowsk R, Doubleday E, Liu Y, Zavala S, Shim E, Reilkoff R, Heneghan J, Eichen S, Goertzen L, Rajala S, Feussom G, Tang B, Junia C, Lichtenberg R, Sidhu H, Espinoza D, Rodrigues S, Zabala M, Goyes D, Susheela A, Hatharaliyadda B, Rameshkumar N, Kasireddy A, Maldonado G, Beltran L, Chaugule A, Khan H, Patil N, Patil R, Cartin-Ceba R, Sen A, Talaei F, Kashyap R, Pablo Domecq J, Gajic O, Bansal V, Tekin A, Lal A, O'Horo J, Deo N, Sharma M, Qamar S, Singh R, Valencia Morales D, La Nou A, Bogojevic M, Zec S, Sanghavi D, Guru P, Morno Franco P, Ganaphadithan K, Saunders H, Fleissner Z, Garcia J, Yu Lee Mateus A, Yarrarapu S, Kaur N, Giri A, Mustafa Hasan M, Donepudi A, Khan S, Jain N, Koritala T, Nanchal R, Bergl P, Peterson J, Yamanaka T, Barreras N, Markos M, Fareeduddin A, Mehta R, Venkata C, Engemann M, Mantese A, Tarabichi Y, Perzynski A, Wang C, Kotekal D, Briceno Bierwirth A, Orellana G, Catalasan G, Ahmed S, Matute C, Hamdan A, Salinas I, Nogal G, Tejada A, Chen J, Hope A, Tsagaris Z, Ruen E, Hambardzumyan A, Siddiqi N, Jurado L, Tincher L, Brown C, Aulakh B, Tripathi S, Bandy J, Kreps L, Bollinger D, Scott Stienecker R, Melendez A, Brunner T, Budzon S, Heffernan J, Souder J, Miller T, Maisonneuve A, Redfern R, Shoemaker J, Micham J, Kenney L, Naimy G, J Pulver K, Yehle J, Weeks A, Inman T, Delmonaco B, Franklin A, Heath M, Vilella A, Kutner S, Clark K, Moore D, Anderson H, Rajkumar D, Abunayla A, Heiter J, Zaren H, Smith S, Lewis G, Seames L, Farlow C, Miller J, Broadstreet G, Martinez A, Allison M, Mittal A, Ruiz R, Skaanland A, Ross R, Patel U, Hodge J, Patel K, Dalal S, Kavani H, Joseph S, Bernstein M, Goff I, Naftilan M, Mathew A, Williams D, Murdock S, Ducey M, Nelson K, Block J, Mitchel J, O'Brien C, Cox S, Amzuta I, Shah A, Modi R, Al-Khalisy H, Masuta P, Schafer M, Wratney A, Carter K, Olmos M, Parker B, Quintanilla J, Craig T, Clough B, Jameson J, Gupta N, Jones T, Ayers S, Harrell A, Brown B, Darby C, Page K, Brown A, McAbee J, Belden K, Baram M, Weber D, DePaola R, Xia Y, Carter H, Tolley A, Ferranti M, Steele M, Kemble L, Sethi J, Cheng Han C, Pagliaro J, Husian A, Malhotra A, Zawaydeh Q, Sines B, Bice T, Markotic D, Bosnjak I, Vail E, Nicholson S, Jonas R, Dement A, Tang W, DeRose M, Villarreal R, Dy R, Lardino A, Sharma J, Czieki R, Christopher J, Lacey R, Mashina M, Patel K, Gomaa D, Goodman M, Wakefield D, Spuzzillo A, Shinn II J, Bihorac A, Ozrazgat Baslanti T, Omalay G, Hashemighouchani H, Cupka J, Ruppert M, McGonagill P, Galet C, Hubbard J, Wang D, Allan L, Badheka A, Chegondi M, Nazir U, Rampon G, Riggle J, Dismag N, Akca O, Lenhardt R, Cavallazzi R, Jerde A, Black A, Polidori A, Griffey H, Winkler J, Brenzel T, Alvarez R, Alarocon-Calderon A, Sosa M, Mahabir S, Patel M, Parker P, Admon A, Hanna S, Chanderraj R, Pliakas M, Wolski A, Cirino J, Dandachi D, Regunath H, Camazine M, Geiger G, Njai A, Saad B, Shah F, Chuan B, Rawal S, Piracha M, Tonna J, Levin N, Suslavich K, Tsolinas R, Fica Z, Skidmore C, Stapleton R, Dixon A, Johnson O, Ardren S, Burns S, Raymond A, Gonyaw E, Hodgdon K, Houseger C, Lin B, McQuesten K, Pecott- Grimm H, Sweet J, Ventrone S, Khandelwal N, West T, Caldwell E, Lovelace-Macon L, Garimella N, Dow D, Akhter M, Rahman R, Mulrow M, Wilfong E, Vela K, Khanna A, Harris L, Cusson B, Fowler J, Vaneenenaam D, Mckinney G, Udoh I, Johnson K, Lyons P, Michelson A, Haulf S, Lynch L, Nguyen N, Steinbery A, Braus N, Pattan V, Papke J, Jimada I, Mhid N, Chakola S, Sheth K, Ammar A, Ammar M, Lopez V, Dela Cruz C, Khosla A, Gautam S. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Network Open 2021, 4: e2140568. PMID: 34935924, PMCID: PMC8696573, DOI: 10.1001/jamanetworkopen.2021.40568.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeRisk of ARDSLength of stayInvasive mechanical ventilationMetabolic syndrome criteriaMetabolic syndromeRespiratory distress syndromeSyndrome criteriaDistress syndromeMechanical ventilationCOVID-19ICU LOSIntensive care unit admissionHospital LOSSARS-CoV-2 infectionCare unit admissionMulticenter cohort studySevere COVID-19Hospital mortalityUnit admissionICU admissionAdult patientsCohort studyCommon comorbiditiesControl patientsVariation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group
Garcia M, Johnson S, Bosch N, Sisson E, Sheldrick C, Kumar V, Boman K, Bolesta S, Bansal V, Deo N, Domecq J, Lal A, Christie A, Banner-Goodspeed V, Sanghavi D, Vadgaonkar G, Gajic O, Kashyap R, Walkey A, Mesland J, Henin P, Petre H, Buelens I, Gerard A, Clevenbergh P, Markotić D, Bošnjak I, Garza R, Chu E, Chan V, Gavidia O, Pachon F, Sanchez Y, Kassas M, Badr M, Tawheed A, Tawheed A, Yahia H, Coello J, Perez G, Lizardo A, Guillen G, Soto H, Segu S, Chakraborty T, Joyce E, Vadgaonkar G, Ediga R, Basety S, Dammareddy S, Kasumalla P, Raju U, Manduva J, Kolakani N, Sripathi S, Chaitanya S, Daga M, Agarwal M, Rohtagi I, Papani S, Kamuram M, Agrawal K, Baghel V, Patel K, Mohan S, Jyothisree E, Matsuda W, Suzuki R, Kyo M, Itagaki Y, Kodate A, Suzuki R, Kodate A, Takahashi Y, Moriki K, Hassan-Hanga F, Galadanci H, Gezawa A, Kabara H, Amole T, Kabir H, Haliru D, Ibrahim A, Asghar M, Syed M, Naqvi S, Zabolotskikh I, Zybin K, Sinkov S, Musaeva T, Almazyad M, Alarifi M, Macarambon J, Bukhari A, Albahrani H, Asfina K, Aldossary K, Zdravkovic M, Todorovic Z, Popadic V, Klasnja S, Kovacevic B, Bojicic J, Stevanovic P, Stojakov D, Ignjatovic D, Bojic S, Bobos M, Nenadic I, Zaric M, Djuric M, Djukic V, Teruel S, Martin B, Teruel S, Sili U, Bilgin H, Ay P, Raval A, Franks A, Kharbanda A, Jhajhria S, Fyffe Z, Capizzi S, Alicie B, Green M, Crockarell L, Drennan A, Dubuque K, Fambrough T, Gasaway N, Krantz B, Nebi P, Orga J, Serfass M, Simion A, Warren K, Wheeler C, Woolman C, Christie A, Ashley D, Adiga R, Moyer A, Verghese G, Newsome A, Forehand C, Bruning R, Jones T, Sabov M, Zaidi F, Tissavirasingham F, Malipeddi D, Armaignac D, Parris D, Zuniga M, Vargas I, Boronat V, Hutton A, Kaur N, Neupane P, Sadule-Rios N, Rojas L, Neupane A, Rivera P, Carlos C, Vincent G, Banner-Goodspeed V, Bose S, Kelly L, Joseph M, McGourty M, Capers K, Hoenig B, Karamourtopoulos M, Law A, Kassis E, Walkey A, Waikar S, Garcia M, Colona M, Kibbelaar Z, Leong M, Wallman D, Soni K, Maccarone J, Gilman J, Devis Y, Chung J, Paracha M, Lumelsky D, DiLorenzo M, Abdurrahman N, Johnson S, Zammit K, Patrick J, Loeffler W, Maya R, Tirupathi R, Tang A, Safi A, Green C, Newell J, Gist K, Sayed I, Brinton J, Strom L, Daugherty S, Atkinson S, Shrimpton K, Yamane D, Benjenk I, Prasanna N, Smalls N, Smith M, Snow W, Liptak R, Durant H, Pendleton V, Nanavati A, Mrozowsk R, Liu Y, Zavala S, Zavala S, Shim E, Reilkoff R, Heneghan J, Eichen S, Goertzen L, Rajala S, Feussom G, Tang B, Junia C, Lichtenberg R, Sidhu H, Espinoza D, Rodrigues S, Zabala M, Goyes D, Susheela A, Hatharaliyadda B, Rameshkumar N, Kasireddy A, Maldonado G, Beltran L, Chaugule A, Khan H, Cartin-Ceba R, Sen A, Palacios A, Mahdi G, Kashyap R, Gajic O, Bansal V, Tekin A, Lal A, O’Horo J, Deo N, Sharma M, Qamar S, Domecq J, Singh R, Niven A, La Nou A, Bogojevic M, Mullen B, Sanghavi D, Franco P, Guru P, Gnanapandithan K, Saunders H, Fleissner Z, Garcia J, Yu A, Mateus L, Yarrarapu S, Kaur N, Giri A, Khan S, Domecq J, Jain N, Koritala T, Timmer J, Welker K, Venkata C, Engemann M, Mantese A, Eschler A, Hejna M, Lewandowski E, Kusmierski K, Martin C, Aulakh B, Tripathi S, Bandy J, Kreps L, Bollinger D, Stienecker R, Melendez A, Brunner T, Budzon S, Heffernan J, Souder J, Miller T, Maisonneuve A, Delmonaco B, Franklin A, Heath M, Vilella A, Kutner S, Clark K, Moore D, Anderson I, Rajkumar D, Abunayla A, Heiter J, Zaren H, Smith S, Lewis G, Seames L, Farlow C, Miller J, Broadstreet G, Martinez A, Allison M, Mittal A, Ruiz R, Skaanland A, Ross R, Mohabir P, O’Brien C, Dasani K, Gupta N, Jones T, Ayers S, Harrell A, Brown B, Edwards M, Darby C, Page K, Brown A, McAbee J, Belden K, Baram M, Weber D, DePaola R, Xia Y, Carter H, Tolley A, Barletta M, Ferranti M, Sines B, Bice T, McGonagill P, Galet C, Hubbard J, Wang D, Allan L, Badheka A, Chegondi M, Nazir U, Rampon G, Riggle J, Dismang N, Alvarez R, Alarcon-Calderon A, Sosa M, Mahabir S, Patel M, Dandachi D, Regunath H, Camazine M, Geiger G, Njai A, Saad B, Stapleton R, Dixon A, Johnson O, Ardren S, Burns S, Raymond A, Gonyaw E, Hodgdon K, Housenger C, Lin B, McQuesten K, Pecott-Grimm H, Sweet J, Ventrone S, Khanna A, Harris L, Cusson B, Fowler J, Vaneenenaam D, McKinney G, Udoh I, Johnson K, Pattan V, Papke J, Jimada I, Mhid N, Chakola S, Sheth K, Ammar A, Ammar M, Lopez V, Dela Cruz C, Khosla A, Gautam S. Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group. Critical Care Explorations 2021, 3: e0566. PMID: 34746796, PMCID: PMC8565794, DOI: 10.1097/cce.0000000000000566.Peer-Reviewed Original ResearchTherapeutic dose anticoagulantsCoronavirus disease 2019Disease 2019Hospital variationClinical trialsViral infectionClinical trial evidenceObservational cohort studyUse of hydroxychloroquineRandomized clinical trialsRisk-adjusted mortalityUse of antiviralsCoronavirus disease 2019 (COVID-19) pandemicRisk-adjusted variationRandom effects logistic regression modelDisease 2019 pandemicEffects logistic regression modelsLogistic regression modelsCohort studyMedication useTrial evidenceEvidence-based practiceInternational HospitalMAIN OUTCOMEMedications